Disease burden and macrolide resistance of Mycoplasma pneumoniae infection in adults in the Asia-Pacific region.
Journal
International journal of antimicrobial agents
Journal Volume
64
Journal Issue
2
ISSN
1872-7913
Date Issued
2024-08
Author(s)
DOI
10.1016/j.ijantimicag.2024.107205
Abstract
Objectives: In the Asia-Pacific region, Mycoplasma pneumoniae (MP) could be a notable pathogen responsible for adult community-acquired pneumonia (CAP), with varying prevalence rates. This comprehensive review aimed to explore the epidemiology, clinical manifestations, macrolide resistance, and molecular characteristics of MP in adults across several countries in Asia. Methods: PubMed, Embase, and Google Scholar were searched for relevant articles from 2010–2023 based on the following keywords: adult and Mycoplasma pneumoniae. Results: The prevalence of MP in CAP patients in these countries ranged from 2.1% in Korea to 25.5% in Japan. Macrolide resistance was prominent, particularly in China, with rates ranging 26.9–100%. Clinical manifestations of MP infection included protean extrapulmonary manifestations, and complications such as rhabdomyolysis and thrombocytopenia. Molecular characteristics, especially the multiple locus variable-number tandem-repeat analysis type 4/5/7/2, remained predominant across various countries, emphasising the importance of ongoing surveillance. Conclusions: This review highlights the urgent need for continued monitoring of MP infections, macrolide resistance, and molecular characteristics to inform effective prevention and treatment strategies in the Asia-Pacific region.
Subjects
Asia-Pacific region
Community-acquired pneumonia
Macrolide resistance
Mycoplasma pneumoniae
SDGs
Publisher
Elsevier B.V.
Description
Article number 107205
Type
review