Long-term Nucleos(t)ides Analogues for Chronic Hepatitis B Improve Liver and Spleen Size: A Noninvasive Sonographic Study.
Journal
Journal of medical ultrasound
Journal Volume
25
Journal Issue
3
Pages
161 - 166
ISSN
0929-6441
Date Issued
2017
Author(s)
Chang, Ruei-Hsin
Nyamsuren, Tsolmon
Gyawali, Sarvesh
Fu, Szu-Chieh
Hu, Rui-Ting
Yang, Sien-Sing
Abstract
Histological improvement and regression of liver fibrosis after long-term use of nucleos(t)ides analogues (NUCs) have been documented. The aim of the present investigation was to evaluate the usefulness of traditional sonography to detect hepatic and splenic changes during NUC therapy in chronic hepatitis B (CHB) patients.
A total of 181 CHB patients receiving NUC treatment were enrolled in this study. The study population was divided into three groups 72 cirrhotic, 58 noncirrhotic CHB, and 51 nonreplicative hepatitis B virus carriers. All patients had blood chemistries taken and sonography at baseline and during the NUC treatment period. The changes in liver size, liver edge, spleen size, platelet count, and platelet count/spleen diameter (PC/SD) ratio were compared among the three groups of patients.
CHB Patients with and without cirrhosis have improved clinical features during NUC therapy with lower aspartate aminotransferase, alanine aminotransferase, international normalized ratio, hepatitis B virus DNA, and spleen size and higher platelet, liver edge, liver size, and PC/SD ratio compared with the baseline data ( < 0.05). The differences in liver edge, liver size, spleen size, and PC/SD ratio are higher in the cirrhosis group than in the non-cirrhotic group ( < 0.001). A decrease in spleen size exhibited a linear relationship with treatment duration ( = 0.905).
Traditional sonography is helpful to monitor changes in liver fibrosis of CHB patients under NUC therapy. AFP, α-fetoprotein; ALT, alanine transaminase; AST, aspartate transaminase; CHB, chronic hepatitis B; Hb, hemoglobin; HBV, hepatitis B virus; INR, international normalized ratio; NUCs, nucleos(t)ides analogues; PC/SD, platelet count/spleen diameter; WBC, white blood cells.
Subjects
antiviral nucleos(t) ides
cirrhosis
liver
sonography
spleen
SDGs
Type
journal article