New NIR‐Activated Organic Molecule‐Based Nanocomposite as an Efficient Sensitizer for Photothermal and Photodynamic Therapy of Cancer
Journal
Advanced Healthcare Materials
ISSN
2192-2640
2192-2659
Date Issued
2025-04-02
Author(s)
Ming‐Hsin Liu
Zhen‐Jie Gao
Wei‐Yung Huang
Chi‐Hung Hsiao
Vincent Chen
Lee‐Jene Lai
Zi‐Jing Lin
Mo D.‐S. Hua
Chia‐Chun Hsieh
Er‐Yuan Chuang
Abstract
Acceptor–donor–acceptor (A–D–A)-configured molecules with coplanar dithieno[2,3-d:2′,3′-d’]thieno[3,2-b:3′,2′-b’]dipyrrole (DTPT) as the core are promising organic semiconductor materials utilized in organic photovoltaic devices owing to their efficient charge transportation capabilities. In addition to optoelectronic applications, they are potential in photothermal and photodynamic applications due to their light-absorption properties. This study evaluates the utilization of DTPT-based fused-ring-conjugated small molecules with strong near-infrared (NIR) absorption as stable organic photosensitizers for phototherapy by forming nanoparticles (NPs) with D-α-tocopherol polyethylene glycol 1000 succinate (TPGS). Among them, NPs prepared from the 2-(3-cyano-4,5,5-trimethylfuran-2(5H)-ylidene)malononitrile (TCF) end-capping DTPT-centered molecule, DTPTTCF, exhibit low cytotoxicity, enhance photothermal conversion efficiency and superior photodynamic activity. In vitro and in vivo experiments demonstrate the remarkable anticancer efficacy of DTPTTCF@TPGS NPs that can effectively suppress cancer cell proliferation under 808 nm laser treatment. Additionally, soft X-ray tomography (SXT) is employed as a high-resolution tool to observe intracellular variations that reveal distinct vacuolization in the NPs + Laser treated group. These observations highlight that the DTPTTCF@TPGS NPs cause significant damage to cancer cells under NIR irradiation. Furthermore, in vivo, experiments demonstrate the apoptosis of cancer cells within tumor tissues and the effective elimination of tumors upon NIR irradiation of DTPTTCF@TPGS NPs treated mice. This work manifests the potential application of the DTPT-cored A–D–A-type molecule as an advanced agent for tumor phototherapy with enhanced efficacy and selectivity.
Subjects
A–D–A-type sensitizer
D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)
near-infrared (NIR) absorption
photodynamic effect
photosensitizer
photothermal effect
Publisher
Wiley
Type
journal article