Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia.
Journal
Blood
Journal Volume
144
Journal Issue
24
Pages
2554 - 2557
ISSN
1528-0020
Date Issued
2024-12-12
Author(s)
Loo, Sun
Potter, Nicola
Ivey, Adam
O'Nions, Jenny
Moon, Roderick
Jovanovic, Jelena
Fong, Chun Y
Anstee, Natasha S
Tiong, Ing Soo
Othman, Jad
Chua, Chong Chyn
Renshaw, Hanna
Baker, Robert
Fleming, Shaun
Russell, Nigel H
Ritchie, David
Bajel, Ashish
Dillon, Richard
Wei, Andrew H
Abstract
Pretransplant detection of KMT2Ar measurable residual disease ≥0.001% by quantitative polymerase chain reaction was associated with significantly inferior posttransplant survival (2-year relapse-free survival 17% vs 59%; P = .001) and increased 2-year cumulative incidence of relapse (75% vs 25%, P = .0004).
SDGs
Type
journal article