Noninvasive Vagus Nerve Electrical Stimulation for Immune Modulation in Sepsis Therapy.
Journal
Journal of the American Chemical Society
Journal Volume
147
Journal Issue
10
Start Page
8406
End Page
8421
ISSN
1520-5126
Date Issued
2025-03-12
Author(s)
Mac, Cam-Hoa
Nguyen, Giang Le Thi
Nguyen, Dien Thi My
Huang, Sheng-Min
Peng, Hsu-Hsia
Chang, Yen
Lo, Shih-Kai
Chiang, Hui-Hua Kenny
Yang, Yuan-Zhen
Lin, Yu-Jung
Sung, Hsing-Wen
Abstract
Sepsis presents a significant medical challenge due to its intense inflammatory response to infection, often resulting in high mortality rates. A promising therapeutic strategy targets the cholinergic anti-inflammatory pathway (CAIP), which regulates immune responses. This study investigates the ingestion of piezoelectric particles that adhere to the stomach lining, specifically targeting TRPV1 receptors. In a mouse model of sepsis, these particles, when activated by low-intensity pulsed ultrasound, generate mild electrical pulses. These pulses stimulate vagal afferent fibers, transmitting signals to the brain and modulating the neural-immune network via the CAIP. Consequently, this leads to a reduction in systemic inflammation, mitigating weight loss, alleviating multiple tissue injuries, and preventing death by modulating immune cells in the spleen. This approach addresses the critical need for noninvasive sepsis therapies, potentially improving patient outcomes. Utilizing portable ultrasound equipment with minimal thermal effects, this technique offers a safe and convenient treatment option, even for home use.
Type
text::journal::journal article