Chronic Kidney Disease and Osteoarthritis: Current Understanding and Future Research Directions
Journal
International Journal of Molecular Sciences
Journal Volume
26
Journal Issue
4
Start Page
1567
ISSN
1422-0067
Date Issued
2025-02-13
Author(s)
Abstract
Chronic kidney disease (CKD) is a significant public health concern. Osteoarthritis (OA), a common form of arthritis, has been shown to have a dramatically increased prevalence, particularly among individuals aged 40-50 and older, in the presence of CKD. Furthermore, CKD may exacerbate the progression and impact of OA. A survey study revealed that 53.9% of CKD patients undergoing long-term hemodialysis were diagnosed with OA. These findings underscore the potential association between CKD and OA. Uremic toxins, such as indoxyl sulfate, p-cresyl sulfate, transforming growth factor-β, and advanced glycation end-products, are regarded as potential risk factors in various CKD-related conditions, affecting bone and joint metabolism. However, whether these factors serve as a bridging mechanism between CKD and OA comorbidities, as well as their detailed roles in this context, remains unclear. Addressing the progression of OA in CKD patients and identifying effective treatment and prevention strategies is an urgent challenge that warrants immediate attention. This review focuses on describing and discussing the molecular pathological mechanisms underlying CKD-associated OA and the possible therapeutic strategies.
Subjects
calcium
chronic kidney disease
iron
osteoarthritis
uremic toxins
SDGs
Publisher
MDPI AG
Type
journal article