Effects of Sofosbuvir/Velpatasvir Therapy on Extrahepatic Manifestations in Patients With Type 2 Diabetes and Chronic Hepatitis C: Insights From a Nationwide Hepatitis C Virus Registry in Taiwan.
Journal
The Kaohsiung journal of medical sciences
ISSN
2410-8650
Date Issued
2025-06-20
Author(s)
Wang, Szu-Jen
Chang, Te-Sheng
Lo, Ching-Chu
Hung, Chao-Hung
Huang, Chien-Wei
Chong, Lee-Won
Cheng, Pin-Nan
Bair, Ming-Jong
Yeh, Ming-Lun
Peng, Cheng-Yuan
Cheng, Chien-Yu
Huang, Jee-Fu
Lin, Chih-Lang
Yang, Chi-Chieh
Kuo, Hsing-Tao
Hsieh, Tsai-Yuan
Lee, Tzong-Hsi
Lee, Pei-Lun
Wu, Wen-Chih
Lin, Chih-Lin
Su, Wei-Wen
Yang, Sheng-Shun
Wang, Chia-Chi
Hu, Jui-Ting
Mo, Lein-Ray
Chen, Chun-Ting
Huang, Yi-Hsiang
Chang, Chun-Chao
Huang, Chia-Sheng
Chen, Guei-Ying
Kao, Chien-Neng
Tai, Chi-Ming
Lee, Mei-Hsuan
Tsai, Pei-Chien
Wang, Shu-Chi
Dai, Chia-Yen
Lin, Han-Chieh
Chuang, Wang-Long
Tseng, Kuo-Chih
Chen, Chi-Yi
Huang, Chung-Feng
Yu, Ming-Lung
Abstract
This study examines the impact of hepatitis C virus (HCV) eradication through sofosbuvir/velpatasvir (SOF/VEL) treatment on glycated hemoglobin (HbA1c) levels in patients with chronic hepatitis C and type 2 diabetes mellitus (T2DM). Utilizing data from the Taiwan HCV Registry, a retrospective analysis was conducted on 2180 patients who met the inclusion criteria, 695 of whom had T2DM. HbA1c levels significantly decreased in the diabetes group from 7.32% ± 1.72% at baseline to 6.87% ± 1.34% after achieving sustained virological response (SVR12). Patients with higher baseline HbA1c levels and cirrhosis experienced more pronounced HbA1c reductions. Among diabetic patients with HbA1c levels ≥ 6.5, 24.6% achieved levels < 6.5 following HCV elimination, while 24.4% of prediabetic patients observed HbA1c reductions < 5.7. Multivariate analysis identified fasting glucose levels and diabetes status as significant factors associated with HbA1c decline. These findings suggest that successful HCV treatment can improve glycemic control, highlighting the need for collaboration between hepatology and non-hepatology specialists in patient care.
Subjects
HbA1c
Taiwan
chronic hepatitis C
real‐world
type 2 diabetes mellitus
SDGs
Type
journal article