Real-world outcomes of selective internal radiation therapy with Y resin microspheres in HCC/mCRC: RESIN registry Asia.
Journal
Future oncology
Journal Volume
21
Journal Issue
18
Start Page
2287
End Page
2297
ISSN
1744-8301
Date Issued
2025-08
Author(s)
Too, Chow Wei
Chotipanich, Chanisa
Venkatanarashima, Nanda
Lo, Richard Hg
Zhuang, Kun Da
Tan, Zehao
Gogna, Apoorva
Ng, David Chee-Eng
Loke, Kelvin Siu-Hoong
Chao, Yee
Worakitsitisatorn, Akeanong
Boonsingma, Nathapol
Lee, Rheun-Chuan
Abstract
Aim: Asia-Pacific guidelines recommend selective internal radiation therapy (SIRT) as an alternative to transarterial chemoembolization for patients with intermediate or advanced hepatocellular carcinoma (HCC) and, in more limited circumstances, for metastatic colorectal cancer (mCRC). This multicenter, single-arm, prospective, observational registry evaluated safety and efficacy of SIRT with 90Y resin microspheres for HCC or mCRC in Asia. Patients & methods: Adults (n = 202) with HCC or mCRC eligible for, and scheduled to receive, SIRT with 90Y resin microspheres at participating centers were recruited. Dosimetry methods used were body surface area or partition model at the physician’s discretion. The primary endpoints were overall response rate (ORR), frequency of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs), and liver function baseline changes. Results: ORR at 3 or 6 months was 56% (HCC) and 33% (mCRC). 491 TEAEs were reported in 125 patients and 71 SAEs were reported in 29 patients. Performance status was maintained or improved in most patients 6 months after SIRT. Conclusion: SIRT may offer clinicians a targeted, single-use approach for HCC or mCRC palliative care or for tumor down-sizing or down-staging in Asia. Controlled trials of SIRT using personalized dosimetry could further define a role for SIRT in these populations.
Subjects
Asia
Hepatocellular carcinoma
metastatic colorectal cancer
registries
selective internal radiation therapy
SDGs
Publisher
Taylor and Francis Ltd.
Type
journal article