OCIAD2 Promotes Cancer Progression via Metabolic Reprogramming in Lung Adenocarcinoma
Journal
Journal of Proteome Research
Journal Volume
24
Journal Issue
8
Start Page
4139-4153
ISSN
1535-3893
1535-3907
Date Issued
2025-07-21
Author(s)
Huang, Yi-Hui
Chang, Wen-Hsin
Shen, Chi-Ya
Chang, Gee-Chen
Lee, Wen-Yao
Chen, Yu-Ju
Abstract
Given the limited proteomic insights and high incidence of lung adenocarcinoma, further investigation of uncharacterized proteins in cancer progression remains crucial. In this study, a poorly characterized protein, OCIA domain-containing 2 (OCIAD2), encoded by chromosome 4 was identified as being upregulated in lung adenocarcinoma from our previous proteogenomics data using the Taiwan Cancer Moonshot cohort. OCIAD2 was highly expressed in tumor tissues in 95.5% of lung adenocarcinoma patients in our cohort, with elevated expression correlating with worse survival. Functional studies revealed that the silencing of the OCIAD2 decreased cell migration, invasion, and colony-forming abilities. Gene Set Enrichment Analysis (GSEA) indicated the involvement of OCIAD2 in oxidative phosphorylation (OXPHOS). Subsequently, mitochondrial metabolic assay demonstrated that OCIAD2 impairs OXPHOS function, accompanied by a metabolic shift toward glycolysis. These findings suggest that OCIAD2 promotes cancer progression through metabolic reprogramming, highlighting the role of OCIAD2 as a potential biomarker and therapeutic target for lung adenocarcinoma.
Subjects
Chromosome-centric Human Proteome Project
Lung adenocarcinoma
Ovarian Cancer Immunoreactive Antigen Domain Containing 2
Uncharacterized protein existence level 1
SDGs
Publisher
American Chemical Society (ACS)
Type
journal article