Comparison of Acute Kidney Disease Staging by Estimated Glomerular Filtration Rate and by Serum Creatinine Ratio in Patients With Dialysis-requiring Acute Kidney Injury: A National Cohort Study From Taiwan
Journal
Kidney Medicine
Journal Volume
7
Journal Issue
11
Start Page
101123
ISSN
2590-0595
Date Issued
2025-11
Author(s)
Teng, Nai-Chi
Chang, Chih-Hsiang
Pan, Heng-Chih
Lin, Ming-Yen
Wang, Shi-Heng
Hsu, Chih-Cheng
Chen, Likwang
Abstract
Rationale & Objective: ), remains uncertain. Our objective is to assess the predictive ability of these staging systems concerning outcomes. Study Design: Population-based retrospective observational cohort study. Setting & Participants: In total, 40,849 hospitalized patients with acute kidney injury requiring dialysis between July 1, 2015 and June 30, 2022, in the Taiwan National Health Insurance Research Database. Tests Compared: ). Cox proportional hazard models were constructed to examine associations between AKD stages and outcomes. Outcomes: Mortality and sustained kidney recovery. Results: staging system, hazard ratios and 95% confidence intervals for mortality across ascending stages were 0.84 (0.75-0.94), 0.90 (0.77-1.04), 0.93 (0.75-1.16), and 4.32 (4.18-4.47). Subgroup and sensitivity analyses yielded consistent results. Limitations: Retrospective analysis based on a claims database. Conclusions: staging system in patients with acute kidney injury requiring dialysis regarding all-cause mortality and kidney recovery. Future investigations are warranted to evaluate the comparative efficacy in patients with acute kidney injury not requiring dialysis.
SDGs
Publisher
Elsevier BV
Type
journal article