A 90 g/day low-carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial.
Journal
Journal of diabetes investigation
Journal Volume
16
Journal Issue
8
ISSN
2040-1124
Date Issued
2025-08
Author(s)
Wang, Yu-Ting
Huang, Wei-Sheng
Chen, Hui-Chuen
Lee, Long-Teng
Huang, Hsien-Liang
Abstract
This study explored the glycemic control and Fried frailty criteria of a 90 g/day low-carbohydrate diet (LCD) in older patients with type 2 diabetes over 18 months.Forty-four older patients with type 2 diabetes and HbA1c ≥ 7.5% (58 mmol/mol) at the outpatient clinics were randomly assigned to a 90 g/day LCD or traditional diabetic diet (TDD). The analysis was performed using an intention-to-treat analysis.A total of 42 (95.5%) patients completed the trial. The 18-month mean change from baseline was statistically significant for 2-h glucose (-100.0 ± 57.7 vs -18.6 ± 86.2 mg/dL) and waist circumference (-6.3 ± 7.9 vs -1.7 ± 4.7 cm) between the LCD and TDD groups (P < 0.05). The 18-month mean change from baseline was not significantly different in HbA1c (-1.55 ± 1.0 vs -0.97 ± 1.2; P = 0.097). After intervention, the proportions of robust, pre-frailty, and frailty in the TDD and LCD groups were 20.0% vs 13.6%, 75.0% vs 86.4%, and 5.0% vs 0.0%, respectively (P > 0.05).A 90 g/d LCD reflected improved glycemic control with significantly lower waist circumference without decreasing frailty in older patients with type 2 diabetes.
Subjects
Diabetes
Frailty
Low‐carbohydrate diet
Type
journal article