Non-cystic fibrosis bronchiectasis in Taiwan.
Journal
BMJ open respiratory research
Journal Volume
12
Journal Issue
1
Start Page
Article number e003100
ISSN
2052-4439
Date Issued
2025-10-02
Author(s)
Sheu, Chau-Chyun
Wang, Ping-Huai
Hsieh, Meng-Heng
Hsu, Wu-Huei
Chen, Ming-Tsung
Ou, Wei-Fan
Wei, Yu-Feng
Yang, Tsung-Ming
Lan, Chou-Chin
Wang, Cheng-Yi
Lin, Chih-Bin
Lin, Ming-Shian
Wang, Yao-Tung
Lin, Ching-Hsiung
Liu, Shih-Feng
Cheng, Meng-Hsuan
Cheng, Wen-Chien
Peng, Chung-Kan
Chan, Ming-Cheng
Jao, Lun-Yu
Chen, Ching-Yi
Wang, Ya-Hui
Chen, Chi-Jui
Chen, Shih-Pin
Tsai, Yi-Hsuan
Cheng, Shih-Lung
Lin, Horng-Chyuan
Abstract
Introduction Bronchiectasis exhibits substantial heterogeneity across geographic locations and includes a diverse range of aetiologies. Limited large-scale data are available for Southeast Asian countries. Methods This was a multicentre, retrospective, observational cohort study. Between January 2017 and June 2020, comprehensive clinical data were collected on enrolment, and 1-year follow-ups were conducted using an electronic case report form. Results A total of 2753 patients were enrolled. The mean age of the patients was 67 years. Forty-two per cent (1150/2753) of patients were male. The mean modified Reiff score was 5.0±3.3. The proportions of bacteria, tuberculosis and nontuberculous mycobacteria cultured from sputum within 1 year of follow-up were 46% (381/829), 1% (10/829) and 24% (202/829), respectively. The most prevalent bacterial isolate was Pseudomonas aeruginosa (22%), followed by Klebsiella pneumoniae (11%). Airflow obstruction was observed in 32% of patients, and 39% used inhaled bronchodilators. A substantial proportion (57%) of the patients were prescribed mucolytics. Seventeen per cent of the patients experienced severe exacerbations within a year. One-year all-cause mortality rate was 2% (52 of 2563 patients). Female patients demonstrated more severe imaging findings than male patients (modified Reiff score, 5.2 vs 4.6, p<0.001). However, they exhibited less obstructive lung function impairment (26% vs 40%, p<0.001), experienced fewer severe exacerbations (15% vs 20%, p=0.002) and had lower mortality rates (2% vs 5%, p<0.001). The risk of severe exacerbation and mortality increased significantly among patients older than 80 years. Conclusion Although female patients with bronchiectasis exhibited more severe imaging findings, their prognoses were better in Taiwan. Elderly patients older than 80 years had worse prognosis.
Subjects
Bronchiectasis
SDGs
Type
journal article