Does weak gamma entrainment still work? Rethinking the comfort–efficacy trade-off in 40 Hz sensory stimulation
Journal
Journal of Alzheimer’s Disease
Journal Volume
108
Journal Issue
4
Start Page
1517
End Page
1519
ISSN
1387-2877
1875-8908
Date Issued
2025-10-24
Author(s)
Abstract
As 40 Hz sensory stimulation gains attention as a potential treatment for Alzheimer's disease, comfort-focused designs such as invisible spectral flicker and multi-luminaire are increasingly used to promote long-term compliance. However, these systems often produce significantly weaker electroencephalographic entrainment than traditional stroboscopic lights. It is therefore important to question the common assumption that any level of entrainment is sufficient, and consider the possibility of nonlinear or threshold-based mechanisms that may require a minimum entrainment strength for therapeutic effects. The field needs to empirically test the relationship between entrainment strength and outcome, to ensure efficacy is not compromised for comfort.
Subjects
Alzheimer's disease
cognition
electrophysiology
invisible spectral flicker
neurobehavioral
Publisher
SAGE Publications
Type
journal article