Cardiovascular disease as a prognostic factor for mortality in non-cystic fibrosis bronchiectasis: data from the Taiwan Bronchiectasis Research Collaboration.
Journal
ERJ open research
Journal Volume
11
Journal Issue
6
Start Page
Article number 00278-2025
ISSN
2312-0541
Date Issued
2025-11
Author(s)
Cheng, Wen-Chien
Sheu, Chau-Chyun
Wang, Ping-Huai
Hsieh, Meng-Heng
Chen, Ming-Tsung
Ou, Wei-Fan
Wei, Yu-Feng
Yang, Tsung-Ming
Lan, Chou-Chin
Wang, Cheng-Yi
Lin, Chih-Bin
Lin, Ming-Shian
Wang, Yao-Tung
Lin, Ching-Hsiung
Liu, Shih-Feng
Cheng, Meng-Hsuan
Peng, Chung-Kan
Chan, Ming-Cheng
Jao, Lun-Yu
Chen, Ching-Yi
Wang, Ya-Hui
Wang, Yung-Hsuan
Chen, Shih-Pin
Tsai, Yi-Hsuan
Cheng, Shih-Lung
Lin, Horng-Chyuan
Hsu, Wu-Huei
Abstract
Background Non-cystic fibrosis bronchiectasis (NCFB) is linked to an increased incidence of cardiovascular disease (CVD), but its impact on mortality is unclear. This study aimed to assess the effect of CVD on mortality and its relationship with clinical characteristics in NCFB patients. Methods This multicentre retrospective study analysed baseline characteristics and outcomes of 2753 NCFB patients, including 648 with CVD. Univariate and multivariate analyses identified factors associated with CVD and mortality, comparing demographics, comorbidities and pulmonary function between patients with and without CVD. Results Patients with CVD were significantly older (76.4 versus 68.8 years, p<0.001), had higher body mass index (BMI) (22.9 versus 21.5 kg·m−2, p<0.001) and more comorbidities. Age (hazard ratio (HR) 1.046, p<0.001), BMI (HR 1.089, p<0.001) and comorbidity score (HR 1.698, p<0.001) were independent risk factors for CVD. Mortality risk factors in NCFB patients included older age (HR 1.032, p=0.042), Pseudomonas aeruginosa infection (HR 3.353, p=0.002), emergency visits (HR 2.455, p<0.001), COPD (HR 2.563, p=0.005) and CVD (HR 2.146, p=0.015). Conclusion CVD in NCFB is associated with severe clinical profiles and poor outcomes. Older age, higher BMI and comorbidity burden significantly correlate with CVD presence. CVD is an independent risk factor for mortality, highlighting the importance of early identification and management of cardiovascular comorbidities in patients with NCFB.
Type
journal article