In Situ Forming of Nitric Oxide and Electric Stimulus for Nerve Therapy by Wireless Chargeable Gold Yarn-Dynamos
Journal
Advanced Science
Journal Volume
10
Journal Issue
33
Start Page
2303566
ISSN
21983844
Date Issued
2023
Author(s)
Chiang, Min-Ren
Lin, Ya-Hui
Zhao, Wei-Jie
Liu, Hsiu-Ching
Hsu, Ru-Siou
Chou, Tsu-Chin
Lu, Tsai-Te
Lee, I-Chi
Liao, Lun-De
Chiou, Shih-Hwa
Hu, Shang-Hsiu
Abstract
Endogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and electrical stimulation in clinical settings can be challenging due to NO's short half-life and the invasive electrodes required for electrical stimulation. Additionally, there is a lack of tools to spatiotemporally control gas release and electrical stimulation. To address these issues, an ?�electromagnetic messenger??approach that employs on-demand high-frequency magnetic field (HFMF) to trigger NO release and electrical stimulation for restoring brain function in cases of traumatic brain injury is introduced. The system comprises a NO donor (poly(S-nitrosoglutathione), pGSNO)-conjugated on a gold yarn-dynamos (GY) and embedded in an implantable silk in a microneedle. When subjected to HFMF, conductive GY induces eddy currents that stimulate the release of NO from pGSNO. This process significantly enhances neural stem cell (NSC) synapses' differentiation and growth. The combined strategy of using NO and electrical stimulation to inhibit inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury is demonstrated in vivo. © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Subjects
gas therapy
gold nanoparticles
nerve regeneration
nitric oxide
wireless charging
Publisher
John Wiley and Sons Inc
Type
journal article