Oxygen-producing composite dressing activated by photothermal and piezoelectric effects for accelerated healing of infected wounds
Journal
Chemical Engineering Journal
Journal Volume
476
Start Page
146744
ISSN
13858947
Date Issued
2023-11-15
Author(s)
Lai, Yen-Han
Roy Barman, Snigdha
Ganguly, Anindita
Pal, Arnab
Yu, Jui-Han
Chou, Syun-Hong
Huang, E-Wen
Chen, San-Yuan
Abstract
The process of wound healing is often obstructed by the prevalence of bacterial infection at the wound site. Hence, innovative strategies to alleviate infection is extremely necessary to realize effective wound recovery in a timely manner. Here, we report a self-activated composite dressing consisting of piezoelectric and photothermal functional layers for combating wound infection and provide the desired treatment. The synergistic dressing is functionalized with piezoelectric Poly-L-lactic acid (PLLA) which under the effect of ultrasound irradiation controllably generates reactive oxygen species (ROS) for antibacterial activity, thus facilitating the dressing to inhibit the growth of bacteria at the wound bed. Further, the dressing is modified with calcium peroxide (CaO2) which can effectively convert the generated ROS into molecular oxygen (O2) in presence of catalase enzyme for treating chronic hypoxia in the infected wounds. The sustained generation of O2 by the wound dressing augmented the cell proliferation, migration and tissue regeneration aiding in wound healing. By combining the inherent photothermal activity of reduced graphene oxide (rGO), the synergistic dressing under NIR irradiation enhanced the wound recovery by upregulating the heat shock protein 90 (Hsp90) secretion owing to the heat generation on the wounds. The results obtained demonstrate that the self-triggered multifunctional wound dressing is a promising candidate for clinical treatment of infected wounds with a user-friendly interface.
Subjects
Infected wound healing
Nanofiber scaffold
Photothermal
Piezoelectric
Ultrasound
Publisher
Elsevier B.V.
Type
journal article