Extracorporeal Blood Purification with the oXiris® Filter for Patients with Sepsis and Hyperinflammatory Conditions: The Asia-Pacific oXiris Expert Meeting 2024 Consensus Statements.
Journal
Blood purification
Journal Volume
54
Journal Issue
11
Start Page
621
End Page
638
ISSN
1421-9735
Date Issued
2025
Author(s)
Zhang, Ling
Srisawat, Nattachai
Lee, Cheng-Chia
Lee, Dong Hyun
Lee, Kyungho
Liu, Zhanguo
Mohamad Nor, Fariz Safhan
Mustafar, Ruslinda Bt
Peerapornratana, Sadudee
Pham, Huy Minh
Sewa, Sewa Duu Wen
Tang, Gloria Kai Yan
Zhu, Mingli
Yao, Qiang
Wang, Minmin
Bellomo, Rinaldo
Abstract
Extracorporeal blood purification is a technique for reducing elevated levels of inflammatory mediators and/or endotoxins in critically ill patients with sepsis or other hyperinflammatory conditions. The oXiris filter combines endotoxin adsorption, cytokine adsorption, hemofiltration, and anti-thrombosis, and an emerging body of evidence demonstrates its use in critical care patients with hyperinflammatory conditions and acute kidney injury (AKI). A group of Asia-Pacific experts convened to formulate consensus statements for the use of the oXiris filter based on a comprehensive review of publications. After evaluation using a Delphi methodology, 17 statements achieved consensus (three recommendations and 14 practice points). These offer guidance on the initiation, monitoring, and evaluation of treatment with the oXiris filter in patients with sepsis, septic shock, severe COVID-19, or other hyperinflammatory states. We also recommend using the oXiris filter in patients undergoing cardiopulmonary bypass for cardiac surgery who are at risk for developing AKI. Other statements discuss modality, dosage, filter lifespan, anticoagulation, and combining the oXiris filter set with other extracorporeal therapies. Taken together, our statements offer targeted guidance for clinicians on the use of the oXiris filter across different patient populations. Additionally, we highlight the limitations of the current evidence base and identify key areas requiring further research.
Subjects
Acute kidney injury
Adsorption therapy
Continuous renal replacement therapy
Cytokine
Endotoxin
Extracorporeal blood purification
Hemoadsorption
Inflammation
Sepsis/septic shock
oXiris
Type
journal article