Transposition of Tn (a Tn derivative) to the conjugative pCtra plasmid family in pediatric multidrug-resistant community-associated MRSA.
Journal
Antimicrobial Agents and Chemotherapy
Journal Volume
69
Journal Issue
10
ISSN
1098-6596
Date Issued
2025-10
Author(s)
Wan, Tsai-Wen
Shintani, Masaki
Kojima, Kenji K
Moriguchi, Naohiko
Hung, Wei-Chun
Wang, Yu-Ting
Yamamoto, Tatsuo
Abstract
We report the transposition of a 9,045-bp transposon (Tn) carrying the /target-gene-like()/ array to a conjugative plasmid (pCtra) in pediatric multidrug-resistant community-associated methicillin-resistant . Tn contained a 7-bp target site () on the left; an internal on the right, apparently "brought-in" through a circular intermediate; and and in the gene and its neighboring gene, respectively. This transposition enhanced ampicillin resistance and facilitated Tn spread at a frequency of 10.
Subjects
Tn552-II
circular intermediate
community-associated methicillin-resistant Staphylococcus aureus
conjugative plasmid
transposition
Publisher
American Society for Microbiology
Type
journal article