Association of homologous recombination repair gene mutation with clinical prognosis in histological subtypes of epithelial ovarian cancer patients.
Journal
Journal of gynecologic oncology
Journal Volume
37
Journal Issue
3
Start Page
Article number e35
ISSN
2005-0399
Date Issued
2026-05
Author(s)
Abstract
Objective: To investigate the associations of homologous recombination repair (HRR) gene mutations with clinical prognosis in epithelial ovarian cancer (EOC) patients with various histological subtypes.
Methods: The EOC patients treated at our institute from January 2014 to March 2021 were included. Gene mutations were detected using 24 target HRR genes. The associations between HRR gene mutations and clinical outcomes were analyzed.
Results: A total of 318 patients were evaluated, 37 patients had BRCA, and 21 patients had other HRR gene mutations. EOC patients with HRR gene mutations were associated with platinum sensitivity than wild type (82.8% vs. 68.7%, p=0.033), and it remained significant in patients with advanced stage (79.5% vs. 57.6%, p=0.007), serous carcinoma (89.4% vs. 66.2%, p=0.002) or optimal debulking surgery (97.1% vs. 79.1%, p=0.013). In serous carcinoma, advanced stage (hazard ratio [HR]=2.11; p=0.031), HRR mutation (HR=0.62; p=0.021) and 1st line poly(ADP-ribose) polymerase inhibitor (PARPi, HR=0.28; p<0.001) were significant for cancer recurrence. Suboptimal debulking surgery (HR=1.58; p=0.044) and HRR gene mutation (HR=0.33; p=0.001) were important for cancer-related death. In non-serous carcinoma, mucinous carcinoma (HR=3.91; p=0.023), advanced stage (HR=3.10; p<0.001) and suboptimal debulking surgery (HR=2.63; p=0.001) were significant for cancer recurrence. Mucinous carcinoma (HR=9.17; p=0.001), advanced stage (HR=4.26; p<0.001), and suboptimal debulking surgery (HR=3.80; p<0.001) were important for cancer-related death.
Conclusion: HRR gene mutations were associated with platinum sensitivity, PARPi response and favorable survival in serous EOC patients. In non-serous EOC, HRR gene mutations did not show the same trend, which warrants further investigation.
Subjects
Epithelial Ovarian Cancer
Histological Subtypes
Homologous Recombination Repair Genes
PAPRi
Publisher
Korean Society of Gynecologic Oncology and Colposcopy
Type
journal article