https://scholars.lib.ntu.edu.tw/handle/123456789/87858
標題: | 克弗爾應用於新美容產品之開發研究 | 作者: | 林慶文 | 關鍵字: | 克弗爾;酪胺酸酶;抗氧化;痤瘡;Kefir is a cultured milk beverage produced by microbial action. The purpose of this research is to study the effects of different kefir components on skin properties including skin whitening effect, antioxidative activity and acne treatment. The final aim is enhance the value of dairy products. The skin whitening tests were performed by tyrosinase assay. The melanin synthesis is regulated by tyrosinase, which catalyzes the conversions of tyrosine to dopa and dopa to dopaquinone. Inhibition of tyrosinase activity reduced the melanin production. The results showed that lactic acid had better inhibitory ability agaist melanin synthesis. A vast amount of evidence implicates oxygen-derived free radicals as important causative agents of aging. Therefore, the antioxidative activities of kefir components were determined by cupric ion chelating analysis and results demonstrated that certain kefir components had antioxdative activities. The ability of acne treatment was performed by inhibition of Propionibacterium acne and Staphylococcus epidermidis, which commonly isolated from pustular acne lesions. The results indicated that lactic acid level higher than 60 and 2 10mg/mL could inhibit the growth of Propionibacterium acne and Staphylococcus epidermidis, individually, while no inhibition was found for other components. | 公開日期: | 2005 | 出版社: | 臺北市:國立臺灣大學動物科學技術學系暨研究所 | 摘要: | 克弗爾為一種由乳酸菌及酵母菌共同發酵之酒精發酵乳,本研究旨在探討克弗爾中之不同成分,對於美白、抗氧化及痤瘡治療是否具有功效,以提升畜產品之應用價值。於美白試驗中,主要以酪胺酸酶之抑制活性來做評估。黑色素主要由酪胺酸藉由酪胺酸酶之催化,經過一連串之反應所形成,故減少黑色素的形成可藉由抑制酪胺酸酶活性達成。結果顯示,乳酸在8mg/mL的添加下,於10 分鐘後之黑色素生成可達IC50,濃度提升為10mg/mL時,酪胺酸酶已不具活性。証據顯示自由基的形成對於皮膚老化有顯著影響,故本研究以銅離子螯合能力做為克弗爾抗氧化能力 之指標,推測克弗爾是否具有抗老化之功能。結果發現乳清、肽類、醣類、菌之胞內萃取物均對銅離子產生螯合能力,顯示克弗爾具有明顯之抗氧化活性。對於痤瘡改善,乳酸於濃度為60mg/mL及10mg/mL分別對痤瘡桿菌及表皮葡萄球菌產生抑制能力,相較於此二株菌對酸環境及抗生素耐受性之不同,或許可供治療炎性痤瘡之參考。 |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/16470 | 其他識別: | 932313B002099 | Rights: | 國立臺灣大學動物科學技術學系暨研究所 |
顯示於: | 動物科學技術學系 |
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932313B002099.pdf | 243.25 kB | Adobe PDF | 檢視/開啟 |
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