| 公開日期 | 標題 | 作者 | 來源出版物 | scopus | WOS | 全文 |
1 | 2024 | Doxazosin inhibits vasculogenic mimicry in human non‑small cell lung cancer through inhibition of the VEGF‑A/VE‑cadherin/mTOR/MMP pathway | Hsu, Jui-Ling; Leu, Wohn-Jenn; LIH-CHING HSU ; Hsieh, Chia-Hsun; JIH-HWA GUH | Oncology letters | | | |
2 | 2024 | Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanism | Du, Chi-Min; Leu, Wohn-Jenn; Jiang, Yi-Huei; Chan, She-Hung; Chen, Ih-Sheng; Chang, Hsun-Shuo; LIH-CHING HSU ; Hsu, Jui-Ling; JIH-HWA GUH | Naunyn-Schmiedeberg's archives of pharmacology | | | |
3 | 2024 | A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer | Ye, Pei-Chen; Leu, Wohn-Jenn; Yeh, Tsung-Yu; Hsu, Yu-Tung; Lin, Yi-Chin; Wei, Zi-Yuan; Chen, Yi-Chin; Chiang, Yi-Chang; Hsu, Jui-Ling; Chan, She-Hung; LIH-CHING HSU ; JI-WANG CHERN ; CHAO-WU YU ; JIH-HWA GUH | The Prostate | | | |
4 | 2023 | Mechanistic study of dual-function inhibitors targeting topoisomerase II and Rad51-mediated DNA repair pathway against castration-resistant prostate cancer | Chiang, Yi-Chang; Leu, Wohn-Jenn; Chen, Yi-Chin; Ye, Pei-Chen; Hsu, Yu-Tung; Hsiao, Yu-Chi; Hsu, Jui-Ling; Chan, She-Hung; LIH-CHING HSU ; Huang, Hsu-Shan; JIH-HWA GUH | The Prostate | | | |
5 | 2023 | Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma Cells | Hsu, Ya-Fen; FAN-LU KUNG ; Huang, Tzu-En; Deng, Yi-Ning; JIH-HWA GUH ; Marchetti, Paolo; Marchesi, Elena; Perrone, Daniela; Navacchia, Maria Luisa; LIH-CHING HSU | Molecules (Basel, Switzerland) | 3 | 3 | |
6 | 2022 | Discovery of New Glucose Uptake Inhibitors as Potential Anticancer Agents by Non-Radioactive Cell-Based Assays | Hung, Hsueh-Chih; Li, Li-Cheng; JIH-HWA GUH ; FAN-LU KUNG ; LIH-CHING HSU | Molecules (Basel, Switzerland) | 3 | 1 | |
7 | 2022 | The Combination of a Novel GLUT1 Inhibitor and Cisplatin Synergistically Inhibits Breast Cancer Cell Growth By Enhancing the DNA Damaging Effect and Modulating the Akt/mTOR and MAPK Signaling Pathways | Weng, Hao-Cheng; Sung, Chieh-Ju; Hsu, Jui-Ling; Leu, Wohn-Jenn; JIH-HWA GUH ; FAN-LU KUNG ; LIH-CHING HSU | Frontiers in pharmacology | 9 | 6 | |
8 | 2021 | Characterization of a fluorescent glucose derivative 1-NBDG and its application in the identification of natural SGLT1/2 inhibitors | Kao, Ting-Yu; Wu, Hwa-Wei; SHOEI-SHENG LEE ; PI-HUI LIANG ; JIH-HWA GUH ; LIH-CHING HSU | Journal of food and drug analysis | 3 | 2 | |
9 | 2020 | Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism Studies | Leu W.-J.; Chu J.-C.; Hsu J.-L.; Du C.-M.; Jiang Y.-H.; LIH-CHING HSU ; Huang W.-J.; JIH-HWA GUH | Molecules (Basel, Switzerland) | 8 | 8 | |
10 | 2020 | The (+)-brevipolide H displays anticancer activity against human castration-resistant prostate cancer: The role of oxidative stress and Akt/mTOR/p70S6K dependent pathways in G1 checkpoint arrest and apoptosis | Sheng Y.-H.; Leu W.-J.; Chen C.-N.; Hsu J.-L.; Liu Y.-T.; LIH-CHING HSU ; Hou D.-R.; JIH-HWA GUH | Molecules | 4 | 4 | |
11 | 2020 | Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells | Huang T.-E.; Deng Y.-N.; Hsu J.-L.; Leu W.-J.; Marchesi E.; Capobianco M.L.; Marchetti P.; Navacchia M.L.; JIH-HWA GUH ; Perrone D.; LIH-CHING HSU | Frontiers in Pharmacology | 19 | 18 | |
12 | 2020 | Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling | Hsu J.-L.; Leu W.-J.; LIH-CHING HSU ; Ho C.-H.; SHIH-PING LIU ; JIH-HWA GUH | Frontiers in Oncology | 11 | 9 | |
13 | 2020 | Discovery of novel agents on spindle assembly checkpoint to sensitize vinorelbine-induced mitotic cell death against human non-small cell lung cancers | Chang Y.-C.; Tseng Y.-L.; Leu W.-J.; Du C.-M.; Jiang Y.-H.; LIH-CHING HSU ; Hsu J.-L.; Hou D.-R.; JIH-HWA GUH | International Journal of Molecular Sciences | 2 | 1 | |
14 | 2019 | The combination of MK-2206 and WZB117 exerts a synergistic cytotoxic effect against breast cancer cells | Li Y.-L.; Weng H.-C.; Hsu J.-L.; SHU-WHA LIN ; JIH-HWA GUH ; LIH-CHING HSU | Frontiers in Pharmacology | 24 | 22 | |
15 | 2019 | Phosphodiesterase type 5 (PDE5) inhibitors sensitize topoisomerase II inhibitors in killing prostate cancer through PDE5-independent impairment of HR and NHEJ DNA repair systems | Chang J.-F.; Hsu J.-L.; Sheng Y.-H.; Leu W.-J.; Yu C.-C.; Chan S.-H.; Chan M.-L.; LIH-CHING HSU ; SHIH-PING LIU ; JIH-HWA GUH | Frontiers in Oncology | 11 | 13 | |
16 | 2019 | Dihydroartemisinin–Bile Acid Hybridization as an Effective Approach to Enhance Dihydroartemisinin Anticancer Activity | Marchesi E.; Chinaglia N.; Capobianco M.L.; Marchetti P.; Huang T.-E.; Weng H.-C.; JIH-HWA GUH ; LIH-CHING HSU ; Perrone D.; Navacchia M.L. | ChemMedChem | 17 | 17 | |
17 | 2018 | Para-toluenesulfonamide induces anti-tumor activity through Akt-dependent and -independent mTOR/p70S6K pathway: Roles of lipid raft and cholesterol contents | Hsu J.-L.; Leu W.-J.; LIH-CHING HSU ; SHIH-PING LIU ; Zhong N.-S.; JIH-HWA GUH | Frontiers in Pharmacology | 10 | 19 | |
18 | 2017 | Enantiomerically pure β-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathways | Chan M.-L.; Yu C.-C.; Hsu J.-L.; Leu W.-J.; Chan S.-H.; LIH-CHING HSU ; SHIH-PING LIU ; Ivantcova P.M.; Dogan ?.; Br?se S.; Kudryavtsev K.V.; JIH-HWA GUH | Oncotarget | 8 | 8 | |
19 | 2016 | Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: The role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways | Leu W.-J.; Swain S.P.; Chan S.-H.; Hsu J.-L.; SHIH-PING LIU ; Chan M.-L.; Yu C.-C.; LIH-CHING HSU ; Chou Y.-L.; Chang W.-L.; Hou D.-R.; JIH-HWA GUH | Oncotarget | 14 | 14 | |
20 | 2016 | Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth | Lai W.-T.; Cheng K.-L.; Baruchello R.; Rondanin R.; Marchetti P.; Simoni D.; Lee R.M.; JIH-HWA GUH ; LIH-CHING HSU | Biochemical Pharmacology | 7 | 7 | |
21 | 2015 | Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult | Chan M.-L.; Liang J.-W.; LIH-CHING HSU ; Chang W.-L.; SHOEI-SHENG LEE ; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 39 | 33 | |
22 | 2015 | Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer - A crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation | Chang W.-L.; LIH-CHING HSU ; Leu W.-J.; Chen C.-S.; JIH-HWA GUH | Oncotarget | 39 | 35 | |
23 | 2015 | Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma | Hsu J.-L.; Liu F.-L.; LIH-CHING HSU ; Chang H.-S.; Leu W.-J.; Yu C.-C.; Chang W.-L.; Chen I.-S.; FAN-LU KUNG ; JIH-HWA GUH | Oncotarget | 8 | 5 | |
24 | 2015 | Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway | Ho C.-H.; Hsu J.-L.; SHIH-PING LIU ; LIH-CHING HSU ; Chang W.-L.; Chao C.C.-K.; JIH-HWA GUH | Prostate | 14 | 14 | |
25 | 2014 | Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle | Leu W.-J.; Chang H.-S.; Chan S.-H.; Hsu J.-L.; Yu C.-C.; LIH-CHING HSU ; Chen I.-S.; JIH-HWA GUH | PLoS ONE | 27 | 24 | |
26 | 2014 | A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway | Hsu J.-L.; SHIH-PING LIU ; Lee C.-C.; LIH-CHING HSU ; Ho Y.-F.; Huang H.-S.; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 13 | 12 | |
27 | 2014 | Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation | Wang W.-T.; Chen Y.-H.; Hsu J.-L.; Leu W.-J.; Yu C.-C.; Chan S.-H.; Ho Y.-F.; LIH-CHING HSU ; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 27 | 25 | |
28 | 2014 | The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cells | Lin Y.-H.; Chen B.Y.-H.; Lai W.-T.; Wu S.-F.; JIH-HWA GUH ; ANN-LII CHENG ; LIH-CHING HSU | Naunyn-Schmiedeberg's Archives of Pharmacology | 34 | 32 | |
29 | 2013 | Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na+/K+-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades | Chan S.-H.; Leu W.-J.; LIH-CHING HSU ; Chang H.-S.; Hwang T.-L.; Chen I.-S.; Chen C.-S.; JIH-HWA GUH | Biochemical Pharmacology | 17 | 15 | |
30 | 2013 | Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation | Yu C.-C.; Wu P.-J.; Hsu J.-L.; Ho Y.-F.; LIH-CHING HSU ; Chang Y.-J.; Chang H.-S.; Chen I.-S.; JIH-HWA GUH | Prostate | 25 | 22 | |
31 | 2012 | Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair | Hsu J.-L.; Leong P.-K.; Ho Y.-F.; LIH-CHING HSU ; Lu P.-H.; Chen C.-S.; JIH-HWA GUH | Cancer Letters | 23 | 17 | |
32 | 2012 | Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway | Hsu J.-L.; Ho Y.-F.; TSAI-KUN LI ; Chen C.-S.; LIH-CHING HSU ; JIH-HWA GUH | Biochemical Pharmacology | 18 | 16 | |