第 1 到 48 筆結果,共 48 筆。
公開日期 | 標題 | 作者 | 來源出版物 | scopus | WOS | 全文 | |
---|---|---|---|---|---|---|---|
1 | 2023 | One-pot tandem reduction and site-selective halogenation of nitroarenes | Dhandabani, Ganesh Kumar; Chang, Li-Te; Hsieh, Hao-Yu; Shih, Chia-Ling; LING-WEI HSIN | Organic & biomolecular chemistry | |||
2 | 2023 | Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities | Chu, Jung-Chun; Tseng, Hui-Ju; Lee, Sung-Bau; Hsu, Kai-Cheng; LING-WEI HSIN ; Liang, Ru-Hao; Lin, Tony Eight; Gao, Nain-Chu; Chen, Liang-Chieh; Lu, Wan-Hsun; Wang, Andrew H-J; Huang, Wei-Jan | Journal of enzyme inhibition and medicinal chemistry | |||
3 | 2022 | 5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome | Chang, Wen-Ying; Yang, Yi-Ting; She, Meng-Ping; CHIA-HUNG TU ; Lee, Tsung-Chun; Wu, Ming-Shiang; CHIN-HUNG SUN ; LING-WEI HSIN ; LINDA CHIA-HUI YU | Laboratory investigation; a journal of technical methods and pathology | 7 | 6 | |
4 | 2021 | Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity | Peng, Cheng; Li, Yu-Hsuan; CHAO-WU YU ; Cheng, Ze-Hua; Liu, Jia-Rong; Hsu, Jui-Ling; LING-WEI HSIN ; Huang, Chen-Tsung; HSUEH-FEN JUAN ; JI-WANG CHERN ; YI-SHENG CHENG | Bioorganic Chemistry | 3 | 2 | |
5 | 2021 | Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors | Hsu K.-C.; Chu J.-C.; Tseng H.-J.; Liu C.-I.; Wang H.-C.; Lin T.E.; Lee H.-S.; LING-WEI HSIN ; Wang A.H.-J.; Lin C.-H.; Huang W.-J. | European Journal of Medicinal Chemistry | 9 | 6 | |
6 | 2020 | Synthesis and analysis of 4-(3-fluoropropyl)-glutamic acid stereoisomers to determine the stereochemical purity of (4S)-4-(3-[18F]fluoropropyl)-L-glutamic acid ([18F]FSPG) for clinical use | Shih, Kai-Ting; Huang, Ya-Yao; Yang, Chia-Ying; MEI-FANG CHENG ; YU-WEN TIEN ; Shiue, Chyng-Yann; RUOH-FANG YEN ; LING-WEI HSIN | PloS one | 4 | 4 | |
7 | 2020 | Synthesis and evaluation of 2-(2′-((dimethylamino)methyl)-4′-(2-fluoroethoxy-substituted)phenylthio)benzenamine derivatives as potential positron emission tomography imaging agents for serotonin transporters | Huang Y.-Y.; Chang L.-T.; Shen H.-Y.; Chen Y.-H.; KAI-YUAN TZEN ; Shiue C.-Y.; LING-WEI HSIN | Bioorganic Chemistry | 0 | 0 | |
8 | 2019 | Prospective comparison of (4S)-4-(3- 18 F-fluoropropyl)-l-glutamate versus 18 F-fluorodeoxyglucose PET/CT for detecting metastases from pancreatic ductal adenocarcinoma: a proof-of-concept study | MEI-FANG CHENG ; Huang Y.-Y.; Ho B.-Y.; TING-CHUN KUO ; LING-WEI HSIN ; Shiue C.-Y.; Kuo H.-C.; YUNG-MING JENG ; RUOH-FANG YEN ; YU-WEN TIEN | European Journal of Nuclear Medicine and Molecular Imaging | 15 | 11 | |
9 | 2019 | High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma | Liu, J.-R.; CHAO-WU YU ; Hung, P.-Y.; LING-WEI HSIN ; JE-RUEI LIU | Biochemical Pharmacology | 57 | 48 | |
10 | 2019 | An one-pot two-step automated synthesis of [18F]T807 injection, its biodistribution in mice and monkeys, and a preliminary study in humans | Huang Y.-Y.; MING-JANG CHIU et al. ; RUOH-FANG YEN ; Tsai C.-L.; Hsieh H.-Y.; Chiu C.-H.; Wu C.-H.; LING-WEI HSIN ; KAI-YUAN TZEN ; Cheng C.-Y.; Ma K.-H.; Shiue C.-Y. | PLoS ONE | 2 | 3 | |
11 | 2019 | A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemia | Lee S.-Y.; LING-WEI HSIN ; MING-JAI SU ; ChangChien C.-C.; Ku H.-C. | Pharmacological Reports | 4 | 4 | |
12 | 2017 | Fast and Facile Synthesis of 4-Nitrophenyl 2-Azidoethylcarbamate Derivatives from N-Fmoc-Protected α-Amino Acids as Activated Building Blocks for Urea Moiety-Containing Compound Library | Chen Y.-Y.; Chang L.-T.; Chen H.-W.; Yang C.-Y.; LING-WEI HSIN | ACS Combinatorial Science | 7 | 7 | |
13 | 2017 | Identification of Buctopamine and Mebuctopamine, a β2 Receptor Agonist and Its Metabolite, in Swine Hair and Feed Additives | Chen Y.-H.; Yang C.-Y.; Cheng C.W.; Lin Y.-Y.; Kuo S.L.; LING-WEI HSIN | Journal of Agricultural and Food Chemistry | 2 | 3 | |
14 | 2017 | Targeting breast cancer stem cells by novel HDAC3-selective inhibitors | Hsieh H.-Y.; Chuang H.-C.; Shen F.-H.; Detroja K.; LING-WEI HSIN ; Chen C.-S. | European Journal of Medicinal Chemistry | 54 | 51 | |
15 | 2016 | A Novel potential positron emission tomography imaging agent for vesicular monoamine transporter type 2 | Huang Z.-R.; Tsai C.-L.; Huang Y.-Y.; Shiue C.-Y.; KAI-YUAN TZEN ; RUOH-FANG YEN ; LING-WEI HSIN | PLoS ONE | 5 | 3 | |
16 | 2016 | Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain | Freyberg Z.; Sonders M.S.; Aguilar J.I.; Hiranita T.; Karam C.S.; Flores J.; Pizzo A.B.; Zhang Y.; Farino Z.J.; Chen A.; Martin C.A.; Kopajtic T.A.; Fei H.; Hu G.; Lin Y.-Y.; Mosharov E.V.; McCabe B.D.; Freyberg R.; Wimalasena K.; LING-WEI HSIN ; Sames D.; Krantz D.E.; Katz J.L.; Sulzer D.; Javitch J.A. | Nature Communications | 88 | 79 | |
17 | 2015 | Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers | Hsieh M.-H.; Tsai C.-H.; Hung J.-J.; TSAI-KUN LI ; SHU-CHUN TENG ; Chang L.-T.; LING-WEI HSIN ; Teng S.-C. | Cellular and Molecular Life Sciences | 8 | 9 | |
18 | 2015 | Activation of serotonin 5-HT7 receptor induces coronary flow increase in isolated rat heart | Chang Chien C.-C.; LING-WEI HSIN ; MING-JAI SU | European Journal of Pharmacology | 13 | 10 | |
19 | 2013 | Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease | CHAO-WU YU ; Chang P.-T.; LING-WEI HSIN ; Chern J.-W. | Journal of Medicinal Chemistry | 90 | 82 | |
20 | 2012 | Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles | Lee C.-H.; Hsieh M.-Y.; LING-WEI HSIN ; Chen H.-C.; Lo S.-C.; Fan J.-R.; Chen W.-R.; Chen H.-W.; NEI-LI CHAN ; TSAI-KUN LI | Biochemical Pharmacology | 12 | 12 | |
21 | 2010 | Synthesis and opioid activity of enantiomeric N-substituted 2,3,4,4a,5,6,7, 7a-octahydro-1H-benzofuro[3,2-e]isoquinolines | LING-WEI HSIN ; Chang L.-T.; Rothman R.B.; Dersch C.M.; Fishback J.A.; Matsumoto R.R. | Journal of Medicinal Chemistry | 12 | 11 | |
22 | 2010 | Improved enamine-type addition of dehydroaporphine using microwave irradiation | Huang W.-J.; Huang C.-C.; LING-WEI HSIN ; Tsai Y.-M.; Lin C.-T.; Lin J.-H.; SHOEI-SHENG LEE | Tetrahedron Letters | 2 | 2 | |
23 | 2010 | Identification of a novel almost neutral μ-opioid receptor antagonist in CHO cells expressing the cloned human μ-opioid receptor | Sally E.J.; Xu H.; Dersch C.M.; LING-WEI HSIN ; Chang L.-T.; Prisinzano T.E.; Simpson D.S.; Giuvelis D.; Rice K.C.; Jacobson A.E.; Cheng K.; Bilsky E.J.; Rothman R.B. | Synapse | 22 | ||
24 | 2008 | Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates | LING-WEI HSIN ; Wang H.-P.; Kao P.-H.; Lee O.; Chen W.-R.; Chen H.-W.; JIH-HWA GUH ; Chan Y.-L.; His C.-P.; Yang M.-S.; TSAI-KUN LI ; Lee C.-H. | Bioorganic and Medicinal Chemistry | 45 | 41 | |
25 | 2008 | Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: Role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters | LING-WEI HSIN ; Chang L.-T.; Rothman R.B.; Dersch C.M.; Jacobson A.E.; Rice K.C. | Journal of Medicinal Chemistry | 11 | 10 | |
26 | 2008 | WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers | Hsiao C.-J.; TSAI-KUN LI ; Chan Y.-L.; LING-WEI HSIN ; Liao C.-H.; Lee C.-H.; Lyu P.-C.; JIH-HWA GUH | Biochemical Pharmacology | 35 | 32 | |
27 | 2008 | A practical asymmetric synthesis of the ACNO fragment of morphine alkaloids | LING-WEI HSIN ; Chang L.-T.; Liou H.-L. | Synlett | 7 | 6 | |
28 | 2005 | Asymmetric total synthesis of (-)-octahydro-1H-benzofuro[3,2-e] isoquinoline, a partial structure of morphine | LING-WEI HSIN ; Chen C.-W.; Chang L.-T. | Journal of the Chinese Chemical Society | 3 | 3 | |
29 | 2005 | Stereoselective synthesis of morphine fragments trans- and cis-octahydro-1H-benzo[4,5]furo[3,2-e]isoquinolines | LING-WEI HSIN ; Chang L.-T.; Chen C.-W.; Hsu C.-H.; Chen H.-W. | Tetrahedron | 15 | 14 | |
30 | 2005 | The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats | Jutkiewicz E.M.; Wood S.K.; Houshyar H.; LING-WEI HSIN ; Rice K.C.; Woods J.H. | Psychopharmacology | 73 | 67 | |
31 | 2004 | Intramolecular Heck cyclization to the galanthamine-type alkaloids: Total synthesis of (±)-lycoramine | PI-HUI LIANG ; Liu, Jing Ping; LING-WEI HSIN ; Cheng, Chen Yu | Tetrahedron | |||
32 | 2004 | Synthesis of 3-[4-acyl-2-(1-methoxy-1-methylethyl)morpholin-3-yl]- benzonitriles as novel potassium channel openers | Lin M.-S.; LING-WEI HSIN ; Cheng C.-Y. | Journal of the Chinese Chemical Society | 0 | 2 | |
33 | 2003 | Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents | LING-WEI HSIN ; Prisinzano T.; Wilkerson C.R.; Dersch C.M.; Horel R.; Jacobson A.E.; Rothman R.B.; Rice K.C. | Bioorganic and Medicinal Chemistry Letters | 16 | 14 | |
34 | 2003 | Synthesis of galanthamine analogs as acetylcholinesterase inhibitors via intramolecular heck cvclization | PI-HUI LIANG ; LING-WEI HSIN ; Pong S.-L.; Hsu C.-H.; Cheng C.-Y. | Journal of the Chinese Chemical Society | 12 | 12 | |
35 | 2003 | A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl} piperazin-1-yl)-2-phenylpropan-2-ol dimaleate | Prisinzano T.; LING-WEI HSIN ; Folk J.E.; Flippen-Anderson J.L.; George C.; Jacobson A.E.; Rice K.C. | Tetrahedron Asymmetry | 12 | 11 | |
36 | 2002 | Synthesis of 1,4-dihydro-2-phenyl-4,4-bis(4-pyridinylmethyl)-2H-isoquinolin-3-one and related compounds as acetylcholine release enhancers | Lin M.-S.; LING-WEI HSIN ; Tsai H.-B.; Tsai M.-C.; Cheng C.-Y. | Chinese Pharmaceutical Journal | 2 | ||
37 | 2002 | CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists | LING-WEI HSIN ; Tian X.; Webster E.L.; Coop A.; Caldwell T.M.; Jacobson A.E.; Chrousos G.P.; Gold P.W.; Habib K.E.; Ayala A.; Eckelman W.C.; Contoreggi C.; Rice K.C. | Bioorganic and Medicinal Chemistry | 36 | ||
38 | 2002 | Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: Chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy) ethyl]-4-(3-phenylpropyl)piperazine | LING-WEI HSIN ; Dersch C.M.; Baumann M.H.; Stafford D.; Glowa J.R.; Rothman R.B.; Jacobson A.E.; Rice K.C. | Journal of Medicinal Chemistry | 67 | 64 | |
39 | 2002 | N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openers | PI-HUI LIANG ; LING-WEI HSIN ; Cheng, Chen-Yu | Bioorganic and Medicinal Chemistry | 32 | ||
40 | 2001 | The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type 1 | Tian X.; LING-WEI HSIN ; Webster E.L.; Contoreggi C.; Chrousos G.P.; Gold P.W.; Habib K.; Ayala A.; Eckelman W.C.; Jacobson A.E.; Rice K.C. | Bioorganic and Medicinal Chemistry Letters | 20 | 18 | |
41 | 2000 | Synthesis of [3H](4-fluorobutyl)propyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine: A potent radioligand for corticotropin-releasing hormone type 1 receptor | LING-WEI HSIN ; Webster E.L.; Chrousos G.P.; Gold P.W.; Eckelman W.C.; Contoreggi C.; Rice K.C. | Journal of Labelled Compounds and Radiopharmaceuticals | 12 | ||
42 | 2000 | Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: The development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor | LING-WEI HSIN ; Webster E.L.; Chrousos G.P.; Gold P.W.; Eckelman W.C.; Contoreggi C.; Rice K.C. | Bioorganic and Medicinal Chemistry Letters | 22 | 21 | |
43 | 1999 | Oxygenated analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1- [2- [bis (4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents | Lewis D.B.; Matecka D.; Zhang Y.; LING-WEI HSIN ; Dersch C.M.; Stafford D.; Glowa J.R.; Rothman R.B.; Rice K.C. | Journal of Medicinal Chemistry | 58 | 54 | |
44 | 1996 | Novel radical synthesis of morphine fragments spiro[benzofuran-3(2H),4'-piperidine] and octahydro-1H-benzofuro[3,2-e]isoquinoline | Cheng C.-Y.; LING-WEI HSIN ; Liou J.-P. | Tetrahedron | 24 | 21 | |
45 | 1996 | Synthesis of 1,4-bis [(17-normorphinyl)methyl]cubane, a morphine dimer linked by cubane | Cheng C.-Y.; LING-WEI HSIN ; Tao P.-L. | Chinese Pharmaceutical Journal | 0 | ||
46 | 1996 | N-Cubylmethyl substituted morphinoids as novel narcotic antagonists | Cheng C.-Y.; LING-WEI HSIN ; Lin Y.-P.; Tao P.-L.; Jong T.-T. | Bioorganic and Medicinal Chemistry | 27 | 25 | |
47 | 1994 | Synthesis and Opioid Activity of 7-Oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols | Cheng C.-Y.; LING-WEI HSIN ; Tsai M.-C.; Schmidt W.K.; Smith C.; Tam S.W. | Journal of Medicinal Chemistry | 13 | 12 | |
48 | 1992 | Selective Reversible and Irreversible Ligands for the k Opioid Receptor | Cheng C.-Y.; Shou-Chien W.; LING-WEI HSIN ; Tam S.W. | Journal of Medicinal Chemistry | 22 | 20 |