https://scholars.lib.ntu.edu.tw/handle/123456789/350380
標題: | Perfusion characteristics of late radiation injury of parotid glands: Quantitative evaluation with dynamic contrast-enhanced MRI | 作者: | HSIAO-WEN CHUNG | 關鍵字: | Magnetic resonance imaging; Parotid glands; Perfusion; Radiation injury | 公開日期: | 2009 | 卷: | 19 | 期: | 1 | 起(迄)頁: | 94-102 | 來源出版物: | European Radiology | 摘要: | We aimed to quantitatively investigate the alteration of parotid perfusion after irradiation using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) based on a two-compartment tracer kinetic model. This study enrolled 19 patients (53.2 ± 14.9 years) treated by head and neck radiotherapy and 19 age-relevant and sex-matched subjects as a control group. Perfusion parameters (Kel, k21 and A) of parotid glands were analyzed based on the Brix model from T1-weighted DCE-MRI. Suitability of the Brix model was evaluated via Monte Carlo simulation for the goodness-of-fit. Analysis of nonlinear goodness-of-fit showed that the Brix model is appropriate in evaluating the parotid perfusion (R2 = 0.938 ± 0.050). The irradiated parotid glands showed significantly lower Kel(P < 0.0005) and k21 (P < 0.05) and consequently significantly higher value of peak enhancement (P < 0.0005) and time-to-peak (P < 0.0005) compared with non-irradiated ones, suggestive of gradual and prolonged accumulation and delayed wash-out of contrast agent due to increased extracellular extravascular space and decreased vascular permeability in the irradiated glands. Linear regression analysis showed dose-dependent perfusion changes of the irradiated parotid glands. We conclude that quantitative DCE-MRI is a potential tool in investigating parotid gland perfusion changes after radiotherapy. ? European Society of Radiology 2008. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-59249108362&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/350380 |
DOI: | 10.1007/s00330-008-1104-9 | SDG/關鍵字: | gadolinium pentetate; adult; article; blood vessel permeability; cancer radiotherapy; clinical article; contrast enhancement; controlled study; drug elimination; female; flow kinetics; human; male; nuclear magnetic resonance imaging; parotid gland disease; priority journal; quantitative analysis; radiation dose; radiation injury; tissue perfusion; xerostomia; Adult; Aged; Contrast Media; Female; Gadolinium DTPA; Head and Neck Neoplasms; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parotid Gland; Radiation Injuries; Reproducibility of Results; Sensitivity and Specificity; Xerostomia; Young Adult |
顯示於: | 生醫電子與資訊學研究所 |
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