https://scholars.lib.ntu.edu.tw/handle/123456789/352052
標題: | Mapping functional connectivity based on synchronized CMRO2 fluctuations during the resting state | 作者: | Chang-wei W. Wu Hong Gu Hanbing Lu Elliot A. Stein JYH-HORNG CHEN Yihong Yang |
關鍵字: | BOLD; CMRO2; Functional connectivity; Perfusion | 公開日期: | 四月-2009 | 卷: | 45 | 期: | 3 | 起(迄)頁: | 694 - 701 | 來源出版物: | NeuroImage | 摘要: | Synchronized low-frequency fluctuations in the resting state functional MRI (fMRI) signal have been suggested to be associated with functional connectivity in brain networks. However, the underlying mechanism of this connectivity is still poorly understood, with the synchronized fluctuations could either originate from hemodynamic oscillations or represent true neuronal signaling. To better interpret the resting signal, in the current work, we examined spontaneous fluctuations at the level of cerebral metabolic rate of oxygenation (CMRO2), an index reflecting regional oxygen consumption and metabolism, and thus less sensitive to vascular dynamics. The CMRO2 signal was obtained based on a biophysical model with data acquired from simultaneous blood oxygenation level dependent (BOLD) and perfusion signals. CMRO2-based functional connectivity maps were generated in three brain networks: visual, default-mode, and hippocampus. Experiments were performed on twelve healthy participants during 'resting state' and as a comparison, with a visual task. CMRO2 signals in each of the abovementioned brain networks showed significant correlations. Functional connectivity maps from the CMRO2 signal are, in general, similar to those from BOLD and perfusion. In addition, we demonstrated that the three parameters (M, α and β) in the biophysical model for calculating CMRO2 have negligible effects on the determination of the CMRO2-based connectivity strength. This study provides evidence that the spontaneous fluctuations in fMRI at rest likely originate from dynamic changes of cerebral metabolism reflecting neuronal activity. |
URI: | http://scholars.lib.ntu.edu.tw/handle/123456789/352052 https://www.scopus.com/inward/record.uri?eid=2-s2.0-61449124829&doi=10.1016%2fj.neuroimage.2008.12.066&partnerID=40&md5=24a4ffd2a06d14aef5e9c1fb7a9acda9 |
ISSN: | 10538119 | DOI: | 10.1016/j.neuroimage.2008.12.066 | SDG/關鍵字: | oxygen; adult; article; brain mapping; brain metabolism; cingulate gyrus; controlled study; female; functional magnetic resonance imaging; hippocampus; human; human experiment; male; normal human; oxygen blood level; oxygen consumption; oxygenation; priority journal; task performance; visual cortex; visual stimulation; Adult; Brain; Brain Mapping; Cerebrovascular Circulation; Energy Metabolism; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Models, Biological; Neural Pathways; Oxygen; Rest |
顯示於: | 電機工程學系 |
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