https://scholars.lib.ntu.edu.tw/handle/123456789/370129| Title: | A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis | Authors: | WEI-TSO CHIA | Keywords: | cancer; cavitation; cell necrosis; liposomes; vesicles | Issue Date: | 2012 | Journal Volume: | 51 | Journal Issue: | 40 | Start page/Pages: | 10089-10093 | Source: | Angewandte Chemie - International Edition | Abstract: | Bubbling over: After endocytosis and intracellular trafficking to lysosomes, liposomes containing ammonium bicarbonate can be thermally triggered to generate CO2 bubbles (see scheme). These bubbles grow rapidly and collapse violently to induce transient cavitation, a process that can disrupt the lysosomal membrane and release lysosomal proteases, thus leading to cell necrosis. Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84866995252&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/370129 |
DOI: | 10.1002/anie.201205482 | SDG/Keyword: | Ammonium bicarbonates; cancer; Cell necrosis; Intracellular trafficking; Lysosomal membranes; Transient cavitation; vesicles; Ammonium compounds; Cavitation; Cell death; Enzyme activity; Liposomes; Molecular biology; Carbon dioxide; ammonium carbonate; carbon dioxide; carbonic acid derivative; article; cell survival; chemically induced disorder; drug delivery system; drug effect; flow cytometry; heat; human; lysosome; necrosis; pathology; tumor cell line; Carbon Dioxide; Carbonates; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Flow Cytometry; Hot Temperature; Humans; Lysosomes; Necrosis [SDGs]SDG3 |
| Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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