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  1. NTU Scholars
  2. 生物資源暨農學院
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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/380685
Title: A collaborative study to establish the first National Standard for HIV-1 RNA nucleic acid amplification techniques (NAT) in Taiwan
Authors: Yang, Y.-C.
Yang-Chih Shih, D.
Tsai, M.-H.
Cheng, C.-H.
Cheng, H.-F.
Lo, C.-F.
Wang, D.-Y.
MONG-HSUN TSAI 
Keywords: Human immunodeficiency virus type 1 (HIV-1); Nucleic acid amplification techniques (NAT); Standard
Issue Date: 2013
Journal Volume: 191
Journal Issue: 2
Start page/Pages: 122-127
Source: Journal of Virological Methods 
Abstract: 
The World Health Organization (WHO) International Standard (IS) for human immunodeficiency virus type 1 (HIV-1) RNA is only available in limited amounts. It is critical to use the most common HIV-1 genotype as source for secondary standards, e.g. a National Standard for Taiwan. The objective of this study was to establish the first National Standard for HIV-1 RNA NAT assays in Taiwan. A collaborative study, including eleven laboratories from five different countries, was carried out to establish the HIV-1 RNA National Standard by calibration, in International Units (IU), against the WHO HIV-1 RNA IS. The HIV-1 RNA content for the candidate was quantitated by each laboratory in three independent assays and the results were collected and analyzed statistically. Overall, a high level of agreement among results was achieved from different laboratories. In addition, the stability study indicated that the candidate was stable for 24 months at -80 ± 5. °C. In conclusion, the candidate standard was established as the first National Standard for HIV-1 RNA for use in NAT assays in Taiwan. The standard is intended to be used for the quality control of HIV-1 NAT assays and as a quantitative reference material for HIV-1 NAT assays. ? 2013 Elsevier B.V.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-84878237417&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/380685
DOI: 10.1016/j.jviromet.2013.04.002
metadata.dc.subject.other: article; bioassay; clinical laboratory; clinical study; controlled study; genotype; health care quality; human; Human immunodeficiency virus 1; nonhuman; nucleic acid amplification; priority journal; quality control; quantitative analysis; reference value; standard; Taiwan; HIV Infections; HIV-1; Humans; International Cooperation; Nucleic Acid Amplification Techniques; Reference Standards; RNA, Viral; Taiwan; Viral Load
[SDGs]SDG3
Appears in Collections:生物科技研究所

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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