https://scholars.lib.ntu.edu.tw/handle/123456789/406750
Title: | Effects of glutathione on amyloid fibrillation of hen egg-white lysozyme | Authors: | Wang S.S.-S. Chou S.-W. Liu K.-N. Wu C.-H. |
Keywords: | Amyloid fibril;Lysozyme;Redox composition | Issue Date: | 2009 | Journal Volume: | 45 | Journal Issue: | 4 | Start page/Pages: | 321-329 | Source: | International Journal of Biological Macromolecules | Abstract: | This study examined the effects of glutathione on the fibrillation of hen egg-white lysozyme. We found that the fibrillation of lysozyme was considerably reduced by GSH while no anti-aggregating activity was detected with only GSSG. SDS-PAGE results also revealed that the addition of GSH led to an early occurrence of prominent lysozyme hydrolysis. Moreover, GSH was effective in inhibiting lysozyme fibrillation when GSH was added within 6 days of incubation. We conclude that the attenuation of lysozyme fibrillation is strongly dependent upon the redox environment. Our data may contribute to decipher the molecular mechanism of amyloid fibrillation. ? 2009 Elsevier B.V. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/406750 | ISSN: | 01418130 | DOI: | 10.1016/j.ijbiomac.2009.08.003 |
Appears in Collections: | 化學工程學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.