https://scholars.lib.ntu.edu.tw/handle/123456789/426865
Title: | Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease | Authors: | YA-FANG CHEN SUNG-CHUN TANG Wu Wen-Chau HSIEN-LI KAO Kuo Y.-S. Yang S.-C. |
Issue Date: | 2017 | Publisher: | Nature Publishing Group | Journal Volume: | 7 | Journal Issue: | 1 | Source: | Scientific Reports | Abstract: | Patients with asymptomatic occlusion in the internal carotid arteries (ICA) have been shown to have a better preserved hemodynamic status of the brain as compared to patients with symptoms. This study was aimed to explore the cerebral perfusion alterations in asymptomatic patients using multi-parametric arterial spin-labeling (ASL) magnetic resonance (MR) imaging. Forty-two patients diagnosed with asymptomatic ICA stenosis/occlusion were prospectively included and divided into high-grade (ultrasonographic stenosis ?70%, N = 20) and low-grade groups (N = 22). On a 3-Tesla clinical MR scanner, pseudo-continuous ASL was performed to measure cerebral blood flow CBF, arterial transit time ATT, and flow territory. Fisher's exact test indicates that the high-grade group has higher frequency in asymmetric ATT (p < 10-3) and asymmetric flow territory (p < 10-3) as compared to the low-grade group. The between-group difference in CBF asymmetry is marginal (p = 0.062). Logistic regression further reveals that hemispherical asymmetry in ATT and flow territory is associated with the existence of high-grade ICA stenosis (odds ratio = 12 and 21, respectively), whereas hemispherical asymmetry in CBF is not. Our data suggest that ATT and flow territory may be better predictors of asymptomatic high-grade ICA stenosis diagnosed by carotid ultrasonography than CBF. ? 2017 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019207941&doi=10.1038%2fs41598-017-02094-4&partnerID=40&md5=f4d56cf29907b809bddc5694436562db https://scholars.lib.ntu.edu.tw/handle/123456789/426865 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-017-02094-4 | SDG/Keyword: | aged; asymptomatic disease; brain circulation; brain cortex; carotid artery obstruction; female; human; image processing; internal carotid artery; magnetic resonance angiography; male; middle aged; nuclear magnetic resonance imaging; pathology; pathophysiology; severity of illness index; vascularization; very elderly; Aged; Aged, 80 and over; Asymptomatic Diseases; Carotid Artery, Internal; Carotid Stenosis; Cerebral Cortex; Cerebrovascular Circulation; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Severity of Illness Index |
Appears in Collections: | 醫療器材與醫學影像研究所 |
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