https://scholars.lib.ntu.edu.tw/handle/123456789/444213
標題: | Panax ginseng and salvia miltiorrhiza supplementation abolishes eccentric exercise-induced vascular stiffening: A double-blind randomized control trial | 作者: | Lin, H.-F. Tung, K. Chou, C.-C. Lin, C.-C. Lin, J.-G. Tanaka, H. |
關鍵字: | Arterial stiffness; Inflammation; Muscle damage | 公開日期: | 2016 | 卷: | 16 | 期: | 1 | 來源出版物: | BMC Complementary and Alternative Medicine | 摘要: | Background: Muscle damage induced by unaccustomed or eccentric exercise results in delayed onset vascular stiffening. We tested the hypothesis that a 7-day supplementation of panax ginseng and salvia miltiorrhiza prior to an acute eccentric exercise could attenuate arterial stiffening. Methods: By using a double-blind study placebo-controlled randomized design, subjects were randomly assigned to either the Chinese herb (N = 12) or the placebo group (N = 11) and performed a downhill running (eccentric exercise) trial and a control (seated rest) trial. Results: Muscle soreness increased 1-2 days after exercise similarly in both groups, whereas the herb group demonstrated a faster recovery on active range of motion. Plasma creatine kinase concentration increased significantly at 24h in both groups but the magnitude of increase was attenuated in the herb group. Arterial stiffness as measured by carotid-femoral pulse wave velocity increased significantly at 24h in the placebo group but such increase was absent in the herb group. Flow-mediated dilation did not change in either group. Plasma concentrations of CRP and IL-6 increased in the placebo group but no such increases were observed in the herb group. Changes in arterial stiffness induced by eccentric exercise were associated with the corresponding changes in IL-6 (r = 0.46, P < 0.05). Conclusions: A short-term Chinese herb supplementation of panax ginseng and salvia miltiorrhiza ameliorated the delayed onset vascular stiffening induced by acute downhill running exercise. Trial registration: ClinicalTrials.gov: NCT02007304. Registered Dec. 5, 2013) ? 2016 The Author(s). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/444213 | DOI: | 10.1186/s12906-016-1139-4 | SDG/關鍵字: | C reactive protein; creatine kinase; ginseng extract; herbaceous agent; interleukin 6; placebo; Salvia miltiorrhiza extract; adult; arterial stiffness; artery blood flow; artery disease; Article; C reactive protein blood level; carotid artery; clinical article; controlled study; creatine kinase blood level; diet supplementation; double blind procedure; drug effect; eccentric muscle contraction; femoral artery; human; interleukin 6 blood level; male; muscle disease; muscle exercise; outcome assessment; protein blood level; pulse wave; randomized controlled trial; range of motion; running; seat; treatment duration; treatment response; vasodilatation; arterial stiffness; dietary supplement; drug effects; myalgia; Panax; phytotherapy; running; Salvia miltiorrhiza; young adult; Dietary Supplements; Double-Blind Method; Humans; Male; Myalgia; Panax; Phytotherapy; Running; Salvia miltiorrhiza; Vascular Stiffness; Young Adult |
顯示於: | 體育室 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。