https://scholars.lib.ntu.edu.tw/handle/123456789/507625
Title: | Decrease in interleukin-21 in children suffering with severe atopic dermatitis | Authors: | Lin S.-C. YA-HUI CHUANG YAO-HSU YANG BOR-LUEN CHIANG |
Issue Date: | 2011 | Journal Volume: | 22 | Journal Issue: | 8 | Start page/Pages: | 869-875 | Source: | Pediatric Allergy and Immunology | Abstract: | Background: Atopic dermatitis (AD) is a kind of eczema with an inflammatory, relapsing, non-contagious, and pruritic skin disorder. It is associated with the local infiltration of T helper type 2 (Th2) cells that secrete interleukin (IL)-4 and IL-5. IL-21 is a member of IL-2 family cytokine mainly expressed by activated CD4+ T lymphocytes. Until now, there is no clinical research in the expression of IL-21 in patients with AD. Methods: We analyzed serum levels of total immunoglobulin E (IgE), allergen-specific IgE, and cytokines IL-4, IL-5, IFN-γ, IL-17, and IL-21 in AD cases and controls. In addition, cytokine levels in the culture supernatants of peripheral blood mononuclear cells stimulated with anti-CD3 and anti-CD28 Abs, phytohemagglutin (PHA), or pokeweed mitogen (PWM) were measured. We also assessed clinical skin severity by Scoring of Atopic Dermatitis (SCORAD) index. Results: Our results showed that serum total IgE in the case group was significantly higher than that of control group (365.449±52.945 and 39.243±7.605IU/ml, respectively). Logistic regression analysis system reveals serum levels of IL-21 and IFN-γ are significantly correlated. However, IL-21 and IL-4, IL-21 and IL-5, as well as IL-21 and IL-17 showed no correlation. Conclusion: A significantly decreased level of IL-21 was observed in children suffering with severe AD compared with controls, suggesting that IL-21 may play a role in AD. ? 2011 John Wiley & Sons A/S. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/507625 | ISSN: | 0905-6157 | DOI: | 10.1111/j.1399-3038.2011.01209.x | SDG/Keyword: | CD28 antigen; CD3 antigen; CD4 antigen; gamma interferon; immunoglobulin E; interleukin 17; interleukin 21; interleukin 4; interleukin 5; phytohemagglutinin; pokeweed mitogen; article; atopic dermatitis; CD4+ T lymphocyte; child; clinical article; controlled study; cytokine release; disease severity; female; human; immunoglobulin blood level; male; peripheral blood mononuclear cell; priority journal; Scoring of Atopic Dermatitis index; scoring system; supernatant; T lymphocyte activation; Th2 cell; Antibodies, Monoclonal; Antigens, CD28; Antigens, CD3; Cells, Cultured; Child; Child, Preschool; Dermatitis, Atopic; Disease Progression; Down-Regulation; Female; Humans; Immunoglobulin E; Interferon-gamma; Interleukins; Male; Phytohemagglutinins; Pokeweed Mitogens; Th2 Cells |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
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