https://scholars.lib.ntu.edu.tw/handle/123456789/521719
Title: | A DNA pooling strategy for family-based association studies | Authors: | WEN-CHUNG LEE | Issue Date: | 2005 | Journal Volume: | 14 | Journal Issue: | 4 | Start page/Pages: | 958-962 | Source: | Cancer Epidemiology Biomarkers and Prevention | Abstract: | Genome-wide association scans for disease susceptibility genes of complex diseases require genotyping on a massive scale. A DNA pooling strategy for family-based association studies is described, which is robust to population stratification biases and to errors in pooling. It can achieve a statistical efficiency of 0.95 with ?1 of 8 or fewer genotyping efforts, and an efficiency of 0.90 with ?1 of 16 or fewer efforts compared with individual genotyping. The pooling method described in this article provides a tradeoff between genotyping efforts and subject recruitment efforts. Copyright ? 2005 American Association for Cancer Research. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-16444379528&doi=10.1158%2f1055-9965.EPI-04-0503&partnerID=40&md5=3843bf581d370facef03bb10da603af1 https://scholars.lib.ntu.edu.tw/handle/123456789/521719 |
ISSN: | 1055-9965 | DOI: | 10.1158/1055-9965.EPI-04-0503 | SDG/Keyword: | article; DNA determination; family; gene frequency; genetic association; genetic susceptibility; genome analysis; genotype; priority journal; statistical analysis; Alleles; DNA; Female; Gene Frequency; Gene Pool; Genetics, Population; Genotype; Humans; Male; Probability |
Appears in Collections: | 流行病學與預防醫學研究所 |
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