https://scholars.lib.ntu.edu.tw/handle/123456789/570272
標題: | Increased expression of MCM5 is significantly associated with aggressive progression and poor prognosis of oral squamous cell carcinoma | 作者: | Yu S.-Y. YI-PING WANG JULIA YU-FONG CHANG Shen W.-R. HSIN-MING CHEN CHUN-PIN CHIANG |
公開日期: | 2014 | 出版社: | Blackwell Publishing Ltd | 卷: | 43 | 期: | 5 | 起(迄)頁: | 344-349 | 來源出版物: | Journal of Oral Pathology and Medicine | 摘要: | Background: Overexpression of MCM5 protein has been found to be significantly associated with the progression and prognosis of several human cancers. Methods: This study used immunohistochemistry to examine the expression of MCM5 protein in 97 specimens of oral squamous cell carcinomas (OSCC), 80 specimens of oral epithelial dysplasia (OED, including 31 mild, 29 moderate, and 20 severe OED samples), and 20 specimens of normal oral mucosa (NOM). Results: We found that the mean nuclear MCM5 labeling indices (LIs) increased significantly from NOM (15?±?6%), through mild (25?±?10%), moderate (34?±?9%), and severe OED (43?±?12%), to OSCC samples (61?±?16%, P?0.001). A significant correlation was found between the higher mean nuclear MCM5 LI and OSCCs with site at the tongue (P?=?0.046), larger tumor size (P?=?0.032), positive lymph node metastasis (P?=?0.003), more advanced clinical stage (P?=?0.002), higher histological grade (P?=?0.002), deeper invasion depth (P?=?0.0001), and perineural invasion (P?=?0.0047). Only nuclear MCM5 LI?≧?60% was identified as independent unfavorable prognostic factor by multivariate regression analyses (P?=?0.049). The Kaplan-Meier curve showed that patients with OSCC with a nuclear MCM5 LI?≧?60% had a significantly poorer cumulative survival than those with a nuclear MCM5 LI?60% (log-rank test, P?=?0.0062). Conclusions: The increased expression of MCM5 protein begins at the oral pre-cancerous stage. The higher expression of MCM5 protein is significantly associated with the aggressive progression and poor prognosis of OSCC. ? 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898787738&doi=10.1111%2fjop.12134&partnerID=40&md5=4bf75f26bc159ce689fff642debdafac https://scholars.lib.ntu.edu.tw/handle/123456789/570272 |
ISSN: | 0904-2512 | DOI: | 10.1111/jop.12134 | SDG/關鍵字: | cell cycle protein; MCM5 protein, human; adult; aged; cancer grading; cancer staging; cell nucleus; chemistry; disease course; DNA replication; female; gene expression regulation; human; immunohistochemistry; lymph node metastasis; male; middle aged; mouth mucosa; mouth tumor; precancer; prognosis; secondary; squamous cell carcinoma; survival rate; tongue tumor; tumor invasion; very elderly; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Nucleus; Disease Progression; DNA Replication; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Staging; Precancerous Conditions; Prognosis; Survival Rate; Tongue Neoplasms |
顯示於: | 臨床牙醫學研究所 |
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