https://scholars.lib.ntu.edu.tw/handle/123456789/575852
Title: | Gelatin sponge functionalized with gold/silver clusters for antibacterial application | Authors: | Wang X Guo J Zhang Q Zhu S Liu L Jiang X Wei D.-H Liu R.-S Li L. RU-SHI LIU |
Keywords: | Nanoclusters; Water absorption; antibacterial; Antibacterial materials; Antibacterial properties; Bacterial infections; Bactericidal activity; gelatin; Metal nanoclusters; Physical performance; Gold; antiinfective agent; gelatin; gold; metal nanoparticle; reactive oxygen metabolite; silver; animal; chemistry; drug effect; metabolism; microbial sensitivity test; pig; porosity; Pseudomonas aeruginosa; surface property; wound healing; Animals; Anti-Bacterial Agents; Gelatin; Gold; Metal Nanoparticles; Microbial Sensitivity Tests; Porosity; Pseudomonas aeruginosa; Reactive Oxygen Species; Silver; Surface Properties; Swine; Wound Healing | Issue Date: | 2020 | Journal Volume: | 31 | Journal Issue: | 13 | Source: | Nanotechnology | Abstract: | Pathogenic bacterial infection, especially in the wound, may threaten human health. Developing new antibacterial materials for wound healing is still urgent. Metal nanoclusters have been explored as a novel antibacterial agent. Herein, biomolecule gelatin was chosen as a substrate and functionalized with gold/silver clusters for bacterial killing. Through a simple amidation reaction, gold/silver clusters were successfully conjugated in a gelatin substrate to obtain a Au/Ag@gelatin sponge. The presence of gold/silver clusters modified the porous structure of the gelatin. Thus, the water absorption and water retention of the Au/Ag@gelatin sponge were enhanced. More importantly, the gold/silver clusters show aggregation-enhanced emission and strong reactive oxygen generation, that endow the Au/Ag@gelatin sponge with a good antibacterial property. The good physical performance and favorable bactericidal activity of the Au/Ag@gelatin sponge suggest its potential for application as a wound dressing. ? 2020 IOP Publishing Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077936690&doi=10.1088%2f1361-6528%2fab59eb&partnerID=40&md5=f15847fc115f674b7c04c1cb434038e6 https://scholars.lib.ntu.edu.tw/handle/123456789/575852 |
ISSN: | 9574484 | DOI: | 10.1088/1361-6528/ab59eb | SDG/Keyword: | Nanoclusters; Water absorption; antibacterial; Antibacterial materials; Antibacterial properties; Bacterial infections; Bactericidal activity; gelatin; Metal nanoclusters; Physical performance; Gold; antiinfective agent; gelatin; gold; metal nanoparticle; reactive oxygen metabolite; silver; animal; chemistry; drug effect; metabolism; microbial sensitivity test; pig; porosity; Pseudomonas aeruginosa; surface property; wound healing; Animals; Anti-Bacterial Agents; Gelatin; Gold; Metal Nanoparticles; Microbial Sensitivity Tests; Porosity; Pseudomonas aeruginosa; Reactive Oxygen Species; Silver; Surface Properties; Swine; Wound Healing |
Appears in Collections: | 化學系 |
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