https://scholars.lib.ntu.edu.tw/handle/123456789/580728
Title: | CMOS-based biomolecular diagnosis platform | Authors: | Liu T.-Y Wang I.-S Yen P.-W Lin S.-C Lin K.-C Jheng J.-S Chang D.-Y CHIH-TING LIN |
Keywords: | Diagnosis; Differential amplifiers; Electroosmosis; Microfluidics; Nanosensors; Bio-molecular diagnosis; Biomolecular detections; Differential difference amplifier; Microfluidic pumping; Si nanowire; Smart-sensing technology; Standard CMOS process; Standard CMOS technology; CMOS integrated circuits | Issue Date: | 2017 | Start page/Pages: | 96-100 | Source: | 2017 IEEE 12th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2017 | Abstract: | Personalized diagnosis system has become an important technical pillar toward the next generation healthcare system. Harnessing momentums of CMOS technologies, it is intriguing to integrate medical diagnostic technologies with personalized mobile platforms. In this paper, both microfluidic pumping and biomolecular detection are monolithically implemented by a 0.35μm standard CMOS technology. The sample pumping is achieved by an on-chip travelling-wave electroosmosis (TWEO) device, including phase-shift driving circuits, with microfluidic channels. At the same time, the biomolecular detection is accomplished by a poly-silicon based field-effect sensor device, with a chopper differential-difference amplifier (DDA) based analog-front-end (AFE). This work demonstrates feasibility to integrate personalized diagnosis platform by standard CMOS processes. In addition, it also paves the way toward smart sensing technologies in point-of-care applications. ? 2017 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030854535&doi=10.1109%2fNEMS.2017.8016982&partnerID=40&md5=2ee18fb67f13c760f7e6bf708a987b43 https://scholars.lib.ntu.edu.tw/handle/123456789/580728 |
DOI: | 10.1109/NEMS.2017.8016982 |
Appears in Collections: | 電機工程學系 |
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