https://scholars.lib.ntu.edu.tw/handle/123456789/604401
Title: | Anti-lymphangiogenic diterpenes from the bark of Calocedrus macrolepis var. formosana | Authors: | TZONG-HUEI LEE Hsieh, Chin Lin Wu, Ho Cheng Wang, Shih Wei ANGELA YU-CHEN LIN Hsiao, George Cheng, Ming Jen Hsieh, Wen Tsong Kuo, Yueh Hsiung |
Keywords: | Anti-lymphangiogenesis | Calocedrus macrolepis var.formosana | Diterpenes | Issue Date: | 1-Jan-2021 | Publisher: | Taiwan Food and Drug Administration | Journal Volume: | 29 | Journal Issue: | 4 | Start page/Pages: | 606-621 | Source: | Journal of Food and Drug Analysis | Abstract: | Eight new diterpenes, 6a,7b-dihydroxyferruginol (1), 6a,7a-dihydroxyferruginol (2), 6a-hydroxyhinokiol (3), 4a-hydroxy-7-oxo-18-norabieta-8,11,13-trien-4a-ol (4a), 15,16-dehydrosugiol (5), 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol (6), 7a-acetoxyabieta-8,12-diene-11,14-dione (7), 7a-butyloxyethyloxyabieta-8,12-diene-11,14-dione (8), along withfour known compounds, 6,7-dehydroferruginol (9), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (10), 7a-11-dihydroxy-12-methoxy-8,11,13-abietatriene (11), and 11,14-dihydroxy-8,11,13-abietatrien-7-one (12) were successfully isolatedfrom the bark of Calocedrus macrolepis var. formosana. The structures of all isolates were elucidated by physical data(appearance, UV, IR, optical rotation) and spectroscopic data (1D, 2D NMR, and HREIMS). Compounds 9, 10, 11, and 12 showed promising growth-inhibitory effect on human lymphatic endothelial cells (LECs). Among these compounds, compound 10 exerted the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs. In conclusion, the results revealed the anti-lymphangiogenic potentials of Formosan C. macrolepis var. formosana. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/604401 | ISSN: | 10219498 | DOI: | 10.38212/2224-6614.3375 |
Appears in Collections: | 漁業科學研究所 |
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