https://scholars.lib.ntu.edu.tw/handle/123456789/607265
標題: | Hydrostatic pressure promotes migration and filamin-A activation in fibroblasts with increased p38 phosphorylation and TGF-β production | 作者: | Kao Y.-C Chen Z.-H Wang W.-Y Lee C.-H PO-LING KUO |
關鍵字: | Cell motility;Fibroblast;Filamin;Interstitial hydrostatic pressure;p38;TGF-β;filamin A;mitogen activated protein kinase p38;transforming growth factor beta;filamin;FlnA protein, mouse;Article;cell culture;cell migration;cell motility;controlled study;fibroblast;hydrostatic pressure;MAPK signaling;NIH 3T3 cell line;protein expression;protein function;protein phosphorylation;protein secretion;upregulation;animal;cell motion;cytology;metabolism;mouse;phosphorylation;Animals;Cell Movement;Fibroblasts;Filamins;Hydrostatic Pressure;Mice;NIH 3T3 Cells;p38 Mitogen-Activated Protein Kinases;Phosphorylation;Transforming Growth Factor beta | 公開日期: | 2021 | 卷: | 568 | 起(迄)頁: | 15-22 | 來源出版物: | Biochemical and Biophysical Research Communications | 摘要: | Fibroblast migration is closely regulated by the mechanical characteristics in surrounding microenvironment. While increased interstitial hydrostatic pressure (HP) is a hallmark in many pathological and physiological conditions, little is known about how the HP affects fibroblast motility. Using cell-culture chips with elevated HP conditions, we showed that 20 cmH2O HP significantly accelerated fibroblast migration. The HP-induced migration acceleration was dependent on the augmentation of transforming growth factor-β1, and correlated with the activation of filamin A via the phosphorylation of p38 mitogen-activated protein kinase. Our results suggest that interstitial HP elevation associated with various pathological states could significantly regulate fibroblast migration. ? 2021 The Authors |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108441826&doi=10.1016%2fj.bbrc.2021.06.055&partnerID=40&md5=1fedc877a47e42317d37338cd6838596 https://scholars.lib.ntu.edu.tw/handle/123456789/607265 |
ISSN: | 0006291X | DOI: | 10.1016/j.bbrc.2021.06.055 |
顯示於: | 電機工程學系 |
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