https://scholars.lib.ntu.edu.tw/handle/123456789/627091
Title: | Acetylcorynoline impairs the maturation of mouse bone marrow-derived dendritic cells via suppression of IκB kinase and mitogen-activated protein kinase activities | Authors: | Fu, Ru-Huei Wang, Yu-Chi Liu, Shih-Ping CHING-LIANG CHU Tsai, Rong-Tzong Ho, Yu-Chen Chang, Wen-Lin Chiu, Shao-Chih Harn, Horng-Jyh Shyu, Woei-Cherng Lin, Shinn-Zong |
Keywords: | SIGNAL-TRANSDUCTION PATHWAYS; GENE-EXPRESSION; HERBAL MEDICINE; LPS; SURVIVAL; BIOLOGY; ENDOCYTOSIS; INDUCTION; ALKALOIDS; CCR7 | Issue Date: | 2013 | Publisher: | PUBLIC LIBRARY SCIENCE | Journal Volume: | 8 | Journal Issue: | 3 | Source: | PloS ONE | Abstract: | Dendritic cells (DCs) are major modulators in the immune system. One active field of research is the manipulation of DCs as pharmacological targets to screen novel biological modifiers for the treatment of inflammatory and autoimmune disorders. Acetylcorynoline is the major alkaloid component derived from Corydalis bungeana herbs. We assessed the capability of acetylcorynoline to regulate lipopolysaccharide (LPS)-stimulated activation of mouse bone marrow-derived DCs. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627091 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0058398 |
Appears in Collections: | 免疫學研究所 |
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