Role of placental fibrinogen-like protein 1 in gestational diabetes
Journal
Translational Research
Journal Volume
218
Pages
73
Date Issued
2020-04-01
Author(s)
Kang, Lin
Ou, Horng Yih
Wu, Pensee
Chang, Chih Jen
Wu, Chao Liang
Wu, Hung Tsung
Abstract
© 2020 Elsevier Inc. In view of the increasing prevalence of gestational diabetes mellitus (GDM) and the increased risks of delivering a macrosomic infant, developing preeclampsia, and suffering a perinatal death due to GDM, GDM has emerged as a growing public health problem. Although the placenta was suggested to play a crucial role in the pathology of GDM, the mechanisms that induce the development of GDM are still obscure. Fibrinogen-like protein (FGL)-1 is a hepatokine that plays an important role in hepatogenesis, as well as in nonalcoholic fatty liver disease and diabetes. Although FGL-1 is also expressed by the placenta, the pathophysiological role of FGL-1 in GDM is still unknown. In this study, FGL-1 levels were evaluated in 45 subjects with (n = 16) or without (n = 29) GDM. We found that FGL-1 was mainly expressed by placental trophoblasts, and FGL-1 expression was significantly higher in subjects with GDM. FGL-1 increased trophoblast proliferation through an extracellular signal-regulated kinase 1/2-dependent pathway. In addition, plasma concentrations of FGL-1 were higher in subjects with GDM, and the increased circulating FGL-1 might contribute to systemic insulin resistance. FGL-1 disrupted the gluconeogenic action of insulin in HepG2 cells, and decreased insulin-induced glucose uptake by L6 myotubes. Taken together, placental FGL-1 possibly plays a role in the impairment of insulin function in the development of GDM, and it might be a novel biomarker for diagnosing GDM.
SDGs
Other Subjects
aminotransferase; creatinine; cytokeratin 7; fibrinogen like protein 1; glucose; liver protein; mitogen activated protein kinase 1; mitogen activated protein kinase 3; unclassified drug; uric acid; FGL1 protein, human; fibrinogen; adult; aminotransferase blood level; Article; body mass; cell proliferation; clinical article; controlled study; female; gluconeogenesis; glucose blood level; glucose metabolism; glucose transport; Hep-G2 cell line; human; immunohistochemistry; insulin resistance; L6 cell line; lipid fingerprinting; liver cell; MAPK signaling; myotube; nonalcoholic fatty liver; perinatal death; pregnancy diabetes mellitus; pregnant woman; prevalence; priority journal; real time polymerase chain reaction; syncytiotrophoblast; trophoblast; uric acid blood level; Western blotting; metabolism; physiology; placenta; pregnancy; pregnancy diabetes mellitus; Adult; Diabetes, Gestational; Female; Fibrinogen; Gluconeogenesis; Humans; Placenta; Pregnancy
Publisher
ELSEVIER SCIENCE INC
Type
journal article