https://scholars.lib.ntu.edu.tw/handle/123456789/510909
標題: | Role of placental fibrinogen-like protein 1 in gestational diabetes | 作者: | Kang, Lin HUNG-YUAN LI Ou, Horng Yih Wu, Pensee SHU-HUEI WANG Chang, Chih Jen SHIN-YU LIN Wu, Chao Liang Wu, Hung Tsung |
公開日期: | 1-四月-2020 | 出版社: | ELSEVIER SCIENCE INC | 卷: | 218 | 起(迄)頁: | 73 | 來源出版物: | Translational Research | 摘要: | © 2020 Elsevier Inc. In view of the increasing prevalence of gestational diabetes mellitus (GDM) and the increased risks of delivering a macrosomic infant, developing preeclampsia, and suffering a perinatal death due to GDM, GDM has emerged as a growing public health problem. Although the placenta was suggested to play a crucial role in the pathology of GDM, the mechanisms that induce the development of GDM are still obscure. Fibrinogen-like protein (FGL)-1 is a hepatokine that plays an important role in hepatogenesis, as well as in nonalcoholic fatty liver disease and diabetes. Although FGL-1 is also expressed by the placenta, the pathophysiological role of FGL-1 in GDM is still unknown. In this study, FGL-1 levels were evaluated in 45 subjects with (n = 16) or without (n = 29) GDM. We found that FGL-1 was mainly expressed by placental trophoblasts, and FGL-1 expression was significantly higher in subjects with GDM. FGL-1 increased trophoblast proliferation through an extracellular signal-regulated kinase 1/2-dependent pathway. In addition, plasma concentrations of FGL-1 were higher in subjects with GDM, and the increased circulating FGL-1 might contribute to systemic insulin resistance. FGL-1 disrupted the gluconeogenic action of insulin in HepG2 cells, and decreased insulin-induced glucose uptake by L6 myotubes. Taken together, placental FGL-1 possibly plays a role in the impairment of insulin function in the development of GDM, and it might be a novel biomarker for diagnosing GDM. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/510909 | ISSN: | 19315244 | DOI: | 10.1016/j.trsl.2020.01.001 | SDG/關鍵字: | aminotransferase; creatinine; cytokeratin 7; fibrinogen like protein 1; glucose; liver protein; mitogen activated protein kinase 1; mitogen activated protein kinase 3; unclassified drug; uric acid; FGL1 protein, human; fibrinogen; adult; aminotransferase blood level; Article; body mass; cell proliferation; clinical article; controlled study; female; gluconeogenesis; glucose blood level; glucose metabolism; glucose transport; Hep-G2 cell line; human; immunohistochemistry; insulin resistance; L6 cell line; lipid fingerprinting; liver cell; MAPK signaling; myotube; nonalcoholic fatty liver; perinatal death; pregnancy diabetes mellitus; pregnant woman; prevalence; priority journal; real time polymerase chain reaction; syncytiotrophoblast; trophoblast; uric acid blood level; Western blotting; metabolism; physiology; placenta; pregnancy; pregnancy diabetes mellitus; Adult; Diabetes, Gestational; Female; Fibrinogen; Gluconeogenesis; Humans; Placenta; Pregnancy |
顯示於: | 解剖學暨細胞生物學科所 |
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