Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population
Journal
Psychiatric Genetics
Journal Volume
16
Journal Volume
16
Journal Issue
1
Journal Issue
1
Pages
39-41
Start Page
39
End Page
41
ISSN
0955-8829
Date Issued
2006-02
Author(s)
Liu Y.-L.
Fann C.S.-J.
Wu J.-Y.
Hung S.-I.
Chan H.-Y.
Chen J.-J.
Pan C.-C.
Liu S.-K.
OuYang W.-C.
Chen C.-Y.
Lin J.-J.
Chou F.H.-C.
Chueh C.-M.
Liu W.-M.
Tsuang M.-M.
Faraone S.V.
Tsuang M.T.
Abstract
AKT1 (V-akt murine thymoma viral oncogene homolog 1) is a protein kinase isoform of AKT. Five single-nucleotide polymorphisms, rs3803300, rs1130214, rs3730358, rs2498799 and rs2494732, at the genomic region of AKT1 have been reported to be significantly associated with schizophrenia. We tested for the presence of these five single-nucleotide polymorphisms in a Taiwanese population by genotyping 218 co-affected schizophrenia families. Both single locus and haplotypes analyses showed no association of these single-nucleotide polymorphisms with schizophrenia. These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population. ? 2006 Lippincott Williams & Wilkins.
SDGs
Other Subjects
Akt1 protein; protein kinase B; unclassified drug; AKT1 protein, human; protein kinase B; article; controlled study; diagnostic error; disease predisposition; female; genetic association; genetic polymorphism; genotype; haplotype; human; major clinical study; male; mental patient; priority journal; schizophrenia; single nucleotide polymorphism; Taiwan; genetic marker; genetics; mass spectrometry; schizophrenia; Murinae; Genetic Markers; Haplotypes; Humans; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-akt; Schizophrenia; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Taiwan
Type
journal article