|Title:||Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population||Authors:||Liu Y.-L.
WEI J. CHEN
|Issue Date:||2006||Journal Volume:||16||Journal Issue:||1||Start page/Pages:||39-41||Source:||Psychiatric Genetics||Abstract:||
AKT1 (V-akt murine thymoma viral oncogene homolog 1) is a protein kinase isoform of AKT. Five single-nucleotide polymorphisms, rs3803300, rs1130214, rs3730358, rs2498799 and rs2494732, at the genomic region of AKT1 have been reported to be significantly associated with schizophrenia. We tested for the presence of these five single-nucleotide polymorphisms in a Taiwanese population by genotyping 218 co-affected schizophrenia families. Both single locus and haplotypes analyses showed no association of these single-nucleotide polymorphisms with schizophrenia. These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population. ? 2006 Lippincott Williams & Wilkins.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/476448||DOI:||10.1097/01.ypg.0000180681.80546.f3||SDG/Keyword:||Akt1 protein; protein kinase B; unclassified drug; AKT1 protein, human; protein kinase B; article; controlled study; diagnostic error; disease predisposition; female; genetic association; genetic polymorphism; genotype; haplotype; human; major clinical study; male; mental patient; priority journal; schizophrenia; single nucleotide polymorphism; Taiwan; genetic marker; genetics; mass spectrometry; schizophrenia; Murinae; Genetic Markers; Haplotypes; Humans; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-akt; Schizophrenia; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Taiwan
|Appears in Collections:||醫學系|
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