https://scholars.lib.ntu.edu.tw/handle/123456789/157343
Title: | Immune Responses to Guided Imagery during Breast Cancer Treatment | Authors: | Lengacher, C. A. Bennett, M. P. Gonzalez, L. Gilvary, D. Cox, C. E. Cantor, A. Jacobsen, P. B. Yang, C. Djeu, J. |
Keywords: | guided imagery;immune response;breast cancer;natural killer cells | Issue Date: | 2008 | Start page/Pages: | 205-214 | Source: | Biological Research for Nursing | Abstract: | Background: The use of relaxation and guided imagery to reduce stress and improve immune function has great potential benefits for patients with breast cancer. Methods: This pilot study used a pretest-posttest experimental design with 28 breast cancer patients, aged 25 to 75 years, with the diagnosis of stage 0, 1, or 2 breast cancer. The experimental group received a relaxation and guided imagery intervention and the control group received standard care. The effects of the intervention on immune function were measured by natural killer (NK) cell cytotoxicity and IL-2- activated NK cell activity prior to surgery and 4 weeks postsurgery . NK cell activity was measured using a 15-hr incubation chromium release assay. Cytotoxicity of NK cells was measured against chromium-labeled K- 562 target cells. IL -2 was used to enhance reactivity of NK cells against tumor cells. After incubation for 15 hr, cytotoxicity was measured through the release of radioactive chromium. Results: Significant differences between groups were found at 4 weeks postsurgery, T-tests showed increased NK cell cytotoxicity for the intervention group at 100:1, 50:1, and 25:1 effector cell: target cell ratios (E:T) (p <.01 to p <.05) and increased activation for IL-2 at 100:1, 50:1,25:1,and 12.5:1 (E:T) (p <.01 to p <.05) for the intervention group as compared to the control group. Discussion: These findings suggest that a relaxation intervention such as guided imagery could have an effect on NK cell cytotoxicity and NK cell cytotoxicity after activation with IL-2 in patients undergoing surgery for breast cancer. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/174507 | DOI: | 10.1177/1099800407309374 | SDG/Keyword: | interleukin 2; adult; aged; article; breast tumor; female; human; immunology; middle aged; natural killer cell; psychological aspect; psychotherapy; Adult; Aged; Breast Neoplasms; Female; Humans; Imagery (Psychotherapy); Interleukin-2; Killer Cells, Natural; Middle Aged |
Appears in Collections: | 護理學系所 |
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