https://scholars.lib.ntu.edu.tw/handle/123456789/369406
標題: | Hypolipidemic and Antioxidative Effects of Noni (Morinda citrifolia L.) Juice on High- fat/Cholesterol-Dietary Hamsters | 作者: | Lin, Yi-Ling CHUNG-HSI CHOU Yang, Deng-Jye Chen, Jr-Wei Tzang, Bor-Show YI-CHEN CHEN |
關鍵字: | Hepatic lipid; Noni juice; Peroxisome proliferator-activated receptor-alpha; Serum antioxidant capacity; Serum lipid; Uncoupling protein 2 | 公開日期: | 2012 | 卷: | 67 | 期: | 3 | 起(迄)頁: | 294-302 | 來源出版物: | Plant Foods for Human Nutrition | 摘要: | Noni juice (NJ) is rich in phytochemicals and polysaccharides. Lipid-lowering and antioxidative effects of NJ were investigated in this study. Fifty male hamsters were assigned randomly to one of the following groups: (1) normal diet and distilled water (LFCD); (2) high-fat/cholesterol diet and distilled water (HFCD); (3) HFCD and 3 ml NJ (including 0.20 g solids)/kg BW (NJ_L); (4) HFCD and 6 mL NJ (including 0.40 g solids)/kg BW (NJ_M); (5) HFCD and 9 ml NJ (including 0.60 g solids)/kg BW (NJ_H) for six weeks. NJ supplementation decreased (p < 0.05) serum triacylglycerol, cholesterol, atherogenic index, malondialdehyde levels, and hepatic lipids in HFCD hamsters, whereas serum trolox equivalent antioxidant capacity, glutathione, and fecal lipids in HFCD hamsters were increased (p < 0.05) by NJ supplementation. Although NJ supplementation downregulated (p < 0.05) sterol regulator element binding protein-1c in HFCD hamsters, it upregulated (p < 0.05) hepatic peroxisome proliferator-activated receptor-alpha and uncoupling protein 2 gene expressions in HFCD hamsters. Results demonstrate that NJ promotes cardioprotection in a high-fat/cholesterol diet. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84866737334&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/369406 |
DOI: | 10.1007/s11130-012-0309-x |
顯示於: | 動物科學技術學系 |
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