https://scholars.lib.ntu.edu.tw/handle/123456789/41070
Title: | 不同記憶系統互動之行為與神經機制的探索(2/3) | Authors: | 梁庚辰 | Keywords: | epinephrine;norepinephrine;β-adrenergic receptors;latent learning;contextual memory | Issue Date: | 2005 | Publisher: | 臺北市:國立臺灣大學心理學系暨研究所 | Abstract: | The present study investigated the memory-enhancing effect of epinephrine in a latent learning paradigm and roles of the amygdala and hippocampus in this effect. Male albino rats were exposed to the apparatus for inhibitory avoidance training without receiving any footshock on the first day. They were subjected to the normal training procedure with 0.5 mA/0.5 s footshock on the second day and tested for retention on the third day. Rats with long experience of pre-exposure had better retention than those with short or no experience of pre-exposure. The latent learning effect in a long pre-exposure was impaired by 4% lidocaine infused into the dorsal hippocampus immediately after the pre-exposure experience, while lidocaine infused into the amygdala had no such effect. Epinephrine injected systemically after a short pre-exposure experience caused a dose- and time-dependent facilitation of the latent memory. This effect was attenuated by infusion of 1.0 µg propranolol into the amygdala, but the same treatment administered to the dorsal hippocampus caused no attenuation. Intra-amygdala infusion of norepinephrine immediately after the short pre-exposure experience also caused a dose-dependent facilitation of latent memory. Further, intra-hippocampal infusion of lidocaine significantly attenuated enhancing effects of epinephrine given peripherally or norepinephrine infused into the amygdala shortly after a short pre-exposure experience. The present findings, taken together, suggest that in an inhibitory avoidance task, peripheral epinephrine may work through activating the amygdaloid noradrenergic functions in modulating latent learning of contextual information relying on the dorsal hippocampus. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/9739 | Other Identifiers: | 932413H002004 | Rights: | 國立臺灣大學心理學系暨研究所 |
Appears in Collections: | 心理學系 |
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