https://scholars.lib.ntu.edu.tw/handle/123456789/411231
標題: | Briarenones A-C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum | 作者: | Cheng, Yang Ahmed, Atallah F. Orfali, Raha S. CHANG-FENG DAI Sheu, Jyh Horng |
關鍵字: | Briarellin | Briarenones | Briareum violaceum | Gorgonian;Briarellin; Briarenones; Briareum violaceum; Gorgonian | 公開日期: | 17-二月-2019 | 出版社: | MDPI | 卷: | 17 | 期: | 2 | 來源出版物: | Marine Drugs | 摘要: | © 2019 by the authors. Three new eunicellin-derived diterpenoids of briarellin type, briarenones A-C (1-3), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR. The absolute configuration of 1 was further confirmed by a single crystal X-ray diffraction analysis. The in vitro cytotoxic and anti-inflammatory potentialities of the isolated metabolites were tested against the growth of a limited panel of cancer cell lines and against the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenyl-alanine and cytochalasin B (fMLF/CB)-stimulated human neutrophils, respectively. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/411231 | ISSN: | 1660-3397 | DOI: | 10.3390/md17020120 | SDG/關鍵字: | Briarenones A; Briarenones B; Briarenones C; cytochalasin B; diterpenoid; elastase; unclassified drug; antineoplastic agent; cytochalasin; diterpene; nonsteroid antiinflammatory agent; pancreatic elastase; superoxide; antiinflammatory activity; Article; Briareum violaceum; cancer cell line; Cnidaria; cytotoxicity; drug isolation; drug structure; enzyme release; human; human cell; in vitro study; neutrophil; nuclear magnetic resonance; X ray diffraction; animal; chemistry; conformation; drug effect; isolation and purification; metabolism; molecular model; nuclear magnetic resonance spectroscopy; tumor cell line; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Cnidaria; Cytochalasins; Diterpenes; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Neutrophils; Pancreatic Elastase; Superoxides; X-Ray Diffraction |
顯示於: | 海洋研究所 |
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