https://scholars.lib.ntu.edu.tw/handle/123456789/425365
Title: | Nanoparticle-dendrimer hybrid nanocapsules for therapeutic delivery | Authors: | Jeong Y. Kim S.T. Jiang Y. Duncan B. Kim C.S. Saha K. Yeh Y.-C. Yan B. Tang R. Hou S. Kim C. Park M.-H. Rotello V.M. YI-CHEUN YEH |
Keywords: | cancer therapy;drug delivery;nanocapsule;paclitaxel;sustained drug release | Issue Date: | 2016 | Journal Volume: | 11 | Journal Issue: | 12 | Start page/Pages: | 1571-1578 | Source: | Nanomedicine | Abstract: | Background: Nanocapsules can efficiently encapsulate therapeutic cargo for anticancer drug delivery. However, the controlled release of the payload remains a challenge for effective drug delivery. Materials & methods: We used dithiocarbamate-functionalized PAMAM dendrimer to cross-link the shell of arginine gold nanoparticles stabilized nanocapsule, and controlled the drug release from the nanocapsule. The ability of cross-linked nanocapsule to deliver hydrophobic paclitaxel to B16F10 cells was demonstrated both in vitro and in vivo. Results: Cross-linked nanocapsule possesses tunable stability and modular permeability, and can deliver paclitaxel with improved anticancer efficiency compared with free drug both in vitro and in vivo. Conclusion: Dithiocarbamate chemistry provides a new tool to harness multifactorial colloidal self-assembly for controlled drug delivery for cancer therapy. ? 2016 Future Medicine Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/425365 | ISSN: | 17435889 | DOI: | 10.2217/nnm-2016-0034 |
Appears in Collections: | 高分子科學與工程學研究所 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.