https://scholars.lib.ntu.edu.tw/handle/123456789/473336
Title: | Expression of LEF1 is an independent prognostic factor for patients with oral squamous cell carcinoma | Authors: | Su M.-C. Chen C.-T. Huang F.-I. Chen Y.-L. YUNG-MING JENG Lin C.-Y. |
Issue Date: | 2014 | Publisher: | Elsevier | Journal Volume: | 113 | Journal Issue: | 12 | Start page/Pages: | 934-939 | Source: | Journal of the Formosan Medical Association | Abstract: | Background/Purpose: Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/β-catenin signaling. In this study, we analyzed the clinicopathologic significance of LEF1 expression in oral squamous cell carcinoma (OSCC). Methods: Expression levels of LEF1 in 135 cases of OSCC were determined by immunohistochemistry. The results were correlated with clinicopathologic parameters and patient outcome. Results: LEF1 was only occasionally detected in basal and parabasal cells of nontumorous squamous epithelium. Overexpression of LEF1 was observed in 33 of 135 OSCCs (24%). LEF1 was more frequently expressed in moderately to poorly differentiated cancer (. p=0.0035) and was associated with lymphovascular invasion (. p=0.0252). Overexpression of LEF1 was significantly associated with poor prognosis (. p=0.0176, hazard ratio=1.96, 95% CI=1.02-3.75). Multivariate analysis revealed LEF1expression and margin status to be the significant independent predictors for overall survival. Conclusion: Our study suggests LEF1 expression in OSCC may play an important role in tumor progression and can be served as a predictor of poor prognosis for patients with OSCC. ? 2013. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84918782904&doi=10.1016%2fj.jfma.2013.07.012&partnerID=40&md5=37d4a2d46370ad4d28aa46946aac36fe https://scholars.lib.ntu.edu.tw/handle/123456789/473336 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2013.07.012 | SDG/Keyword: | lymphoid enhancer factor 1; LEF1 protein, human; lymphoid enhancer factor 1; adult; Article; cancer patient; cancer prognosis; controlled study; female; histopathology; human; human tissue; immunohistochemistry; lymph vessel metastasis; major clinical study; male; mouth squamous cell carcinoma; nucleotide sequence; overall survival; protein expression; tumor growth; cancer grading; Carcinoma, Squamous Cell; chemistry; middle aged; minimal residual disease; Mouth Neoplasms; pathology; prognosis; survival rate; tumor invasion; Carcinoma, Squamous Cell; Female; Humans; Lymphoid Enhancer-Binding Factor 1; Male; Middle Aged; Mouth Neoplasms; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm, Residual; Prognosis; Survival Rate |
Appears in Collections: | 病理學科所 |
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