Progress in genetic study on graves' disease
Journal
Journal of Internal Medicine of Taiwan
Journal Volume
12
Journal Issue
3
Pages
111-120
Date Issued
2001
Author(s)
Abstract
Grave's disease is the leading cause of hyperthyroidism. It also has higher prevalence than other organ specific autoimmune diseases. Taking advantage of the genome research and new biostatistical tools, there has been significant progress in genetic study on Grave's disease during the latest 10 years. In this review article, we started with the clinical presentation, laboratory finding, and pathophysiology of Grave's disease. We then summarized the various animal models. Evidence of genetic factors in the etiology of Grave's disease was also examined. The methods for the study of multifactorial polygenic diseases were described. We ended up with the most, update advance in genetic study on Grave's disease. However, most of the studies were restricted to the Caucasian populations. Further investigation on the non-Caucasian populations is necessary, and might provide important insight to this topic.
SDGs
Other Subjects
beta1 integrin; CD2 antigen; CD4 antigen; CD45 antigen; CD8 antigen; thyrotropin; thyroxine; allele; animal experiment; animal model; article; autoimmune disease; biostatistics; Caucasian; chicken; clinical feature; controlled study; gene locus; genetic analysis; genetic linkage; genetic susceptibility; Graves disease; Hashimoto disease; heredity; human; human cell; hyperthyroidism; insulin dependent diabetes mellitus; laboratory test; medical research; mouse; multifactorial genetic disorder; nonhuman; obesity; pathophysiology; phenotype; population research; prevalence; rat; review; thyroid cell
Type
journal article