https://scholars.lib.ntu.edu.tw/handle/123456789/536950
標題: | Use of Lactobacillus casei rhamnosus to Prevent Cholangitis in Biliary Atresia After Kasai Operation | 作者: | Lien T.-H. Bu L.-N. JIA-FENG WU HUEY-LING CHEN Chen A.-C. Lai M.-W. Shih H.-H. Lee I.-H. HONG-YUAN HSU YEN-HSUAN NI MEI-HWEI CHANG |
公開日期: | 2015 | 卷: | 60 | 期: | 5 | 起(迄)頁: | 654-658 | 來源出版物: | Journal of pediatric gastroenterology and nutrition | 摘要: | OBJECTIVES: Recurrent cholangitis may aggravate cholestatic liver cirrhosis in biliary atresia (BA) after the Kasai operation. This pilot study aimed to investigate whether Lactobacillus casei rhamnosus has the prophylactic efficacy for recurrent cholangitis in comparison with the conventional neomycin prophylaxis.METHODS: Twenty jaundice-free patients with BA ages 0 to 3 years who underwent a Kasai operation were enrolled and randomized into 2 groups with 10 patients each: neomycin (25 mg · kg · day for 4 days/wk) and L casei rhamnosus (8?×?10 colony-forming unit per day) groups. The treatment duration was 6 months. Bacterial stool cultures were performed before treatment and 1, 3, and 6 months after starting treatment. In addition, 10 patients with BA with similar status but without prophylaxis served as the historical control group.RESULTS: In the Lactobacillus group, 2 patients (20%, mean 0.03?±?0.07 episodes per month) developed cholangitis during the study period, with the same frequency as in the neomycin group and significantly lower than that in the control group (80%, P?=?0.005, mean 0.22?±?0.16 episodes per month). The mean change in body weight z score during the 6 months in the Lactobacillus group was 0.97?±?0.59, which was significantly better than that in the control group (-0.01?±?0.79, P?=?0.006). In bacterial stool cultures, the Lactobacillus and Escherichia coli populations significantly increased and decreased, respectively, in the Lactobacillus group.CONCLUSIONS: The use of L casei rhamnosus was as effective as neomycin in preventing cholangitis in patients with BA who underwent Kasai operation, and therefore could be considered as a potential alternative prophylactic regimen. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027949873&doi=10.1097%2fMPG.0000000000000676&partnerID=40&md5=f1dc3a71689161b4549d055ca7603e8f https://scholars.lib.ntu.edu.tw/handle/123456789/536950 |
ISSN: | 1536-4801 | DOI: | 10.1097/MPG.0000000000000676 | SDG/關鍵字: | antiinfective agent; neomycin; probiotic agent; adverse effects; Biliary Atresia; body weight; cholangitis; comparative study; controlled study; disease free survival; Escherichia coli; feces; female; human; infant; isolation and purification; Lactobacillus; Lactobacillus casei; Lactobacillus rhamnosus; male; microbiology; newborn; pilot study; portoenterostomy; randomized controlled trial; recurrent disease; Anti-Bacterial Agents; Biliary Atresia; Body Weight; Cholangitis; Disease-Free Survival; Escherichia coli; Feces; Female; Humans; Infant; Infant, Newborn; Lactobacillus; Lactobacillus casei; Lactobacillus rhamnosus; Male; Neomycin; Pilot Projects; Portoenterostomy, Hepatic; Probiotics; Recurrence |
顯示於: | 醫學系 |
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