https://scholars.lib.ntu.edu.tw/handle/123456789/550892
標題: | Correlative analysis of overall survival with clinical characteristics in 127 patients with mantle cell lymphoma: a multi-institutional cohort in Taiwan | 作者: | Wang, Yu-Hung SHAN-CHI YU BOR-SHENG KO YI-TSUNG YANG MING YAO JIH-LUH TANG TAI-CHUNG HUANG |
關鍵字: | Gastric involvement; Mantle cell lymphoma; Multi-institutional; Stem cell transplantation; Taiwan | 公開日期: | 九月-2020 | 出版社: | SPRINGER JAPAN KK | 卷: | 112 | 期: | 3 | 起(迄)頁: | 385 | 來源出版物: | International journal of hematology | 摘要: | Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma often with extranodal involvement at diagnosis, and yet how this feature correlates with survival awaits elucidation. To address this issue, a correlative analysis between clinical features of 127 MCL patients and their overall survival (OS) was conducted. In this cohort, the median age at MCL diagnosis was 62 years and 81% were males. Eighty-four percent of patients were Ann Arbor stage 4, and 15% were blastoid variants. In patients with gastrointestinal MCL, approximately 40% had gastric involvement. In treatment, CHOP-based induction chemotherapy was given to 61.1% of patients. One-third of patients undertook autologous stem cell transplant (SCT), and 4.7% had allogeneic SCT. The median OS was 82 months and well-stratified in MIPI risk groups. In the multivariate analysis for OS, blastoid variants and gastric involvement were both independent risk factors whereas auto-SCT had a protective effect. Overall, this study corroborated with the current understandings and international therapeutic standards for MCL. Auto-SCT associated with a better OS while allo-SCT remained an option for blastoid variants and those who failed Auto-SCT. Interestingly, patients with gastric involvement tended to have worse survival, a finding that spawns more studies to investigate the mechanism. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/550892 | ISSN: | 0925-5710 | DOI: | 10.1007/s12185-020-02903-z | SDG/關鍵字: | asparaginase; bendamustine; bortezomib; chlorambucil; cisplatin; cyclophosphamide; cytarabine; dexamethasone; doxorubicin; gemcitabine; ibrutinib; methotrexate; paclitaxel; prednisolone; prednisone; rituximab; vincristine; antineoplastic agent; cyclophosphamide; doxorubicin; prednisone; vincristine; acute graft versus host disease; adult; aged; allogeneic stem cell transplantation; Article; autologous stem cell transplantation; bleeding; blister; cancer combination chemotherapy; cancer patient; cancer regression; cancer staging; cancer surgery; cancer therapy; clinical feature; cohort analysis; cytopenia; drug megadose; female; fungal sinusitis; gastrointestinal lymphoma; hematothorax; high risk population; human; induction chemotherapy; major clinical study; male; mantle cell lymphoma; middle aged; overall survival; Pneumocystis pneumonia; splenectomy; Taiwan; treatment duration; treatment response; treatment response time; allotransplantation; autotransplantation; clinical trial; epidemiology; gastrointestinal tumor; mantle cell lymphoma; mortality; multicenter study; prognosis; remission; stem cell transplantation; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Cyclophosphamide; Doxorubicin; Female; Gastrointestinal Neoplasms; Humans; Lymphoma, Mantle-Cell; Male; Middle Aged; Prednisone; Prognosis; Remission Induction; Stem Cell Transplantation; Taiwan; Transplantation, Autologous; Transplantation, Homologous; Vincristine |
顯示於: | 病理學科所 |
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